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Honokiol: A review of its pharmacological potential and therapeutic insights.

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机构： [a]Department of Chemistry, University of Swabi, Swabi, Anbar, 23430, Khyber Pakhtunkhwa (KP), Pakistan [b]Department of Biochemistry, Abubakar Tafawa Balewa University, Bauchi, 740272, Nigeria [c]University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, University of Lahore, Pakistan [d]Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. [e]Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia. [f]Pharmakon Neuroscience Research Network, Dhaka, Bangladesh [g]Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh [h]Department of Pharmacy, BGC Trust University Bangladesh, Chittagong-4381, Bangladesh [i]K.G. Razumovsky Moscow State University of Technologies and Management (the First Cossack University), 109004, Moscow, Russian Federation [j]Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russian Federation [k]V. M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, 109029, Moscow, Russian Federation. [l]Ural State Agrarian University, 620075 Yekaterinburg, Russian Federation. [m]West China School of Nursing / Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [n]King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia [o]Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770. Novel Global Community Educational Foundation, Australia

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关键词： Honokiol Magnolol Anti-inflammatory Antioxidant Meuroprotective

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Honokiol is a pleiotropic compound which been isolated from Magnolia species such as Magnolia grandiflora and Magnolia dealbata. Magnolia species Magnolia grandiflora is used in traditional medicine for the treatment of various diseases.The objective of this review is to summarize the pharmacological potential and therapeutic insights of honokiol.Honokiol has been specified as a novel alternative to treat various disorders such as liver cancer, neuroprotective, anti-spasmodic, antidepressant, anti-tumorigenic, antithrombotic, antimicrobial, analgesic properties and others. Therefore, this study designed to represent the in-depth therapeutic potential of honokiol.Literature searches in electronic databases, such as Web of Science, Science Direct, PubMed, Google Scholar, and Scopus, were performed using the keywords 'Honokiol', 'Health Benefits' and 'Therapeutic Insights' as the keywords for primary searches and secondary search terms were used as follows: 'Anticancer', 'Oxidative Stress', 'Neuroprotective', 'Antimicrobial', 'Cardioprotection', 'Hepatoprotective', 'Anti-inflammatory', 'Arthritis', 'Reproductive Disorders'.This promising bioactive compound presented an wide range of therapeutic and biological activities which include liver cancer, neuroprotective, anti-spasmodic, antidepressant, anti-tumorigenic, antithrombotic, antimicrobial, analgesic properties, and others. Its pharmacokinetics has been established in experimental animals, while in humans, this is still speculative. Some of its mechanism for exhibiting its pharmacological effects includes apoptosis of diseased cells, reduction in the expression of defective proteins like P-glycoproteins, inhibition of oxidative stress, suppression of pro-inflammatory cytokines (TNF-α, IL-10 and IL-6), amelioration of impaired hepatic enzymes and reversal of morphological alterations, among others.All these actions displayed by this novel compound could make it serve as a lead in the formulation of drugs with higher efficacy and negligible side effects utilized in the treatment of several human diseases.Copyright © 2021 Elsevier GmbH. All rights reserved.

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出版当年[2021]版：

大类 | 2 区

医学

小类 | 1 区植物科学 1 区全科医学与补充医学 1 区药学 2 区药物化学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区药物化学 1 区全科医学与补充医学 1 区药学 1 区植物科学

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第一作者机构： [a]Department of Chemistry, University of Swabi, Swabi, Anbar, 23430, Khyber Pakhtunkhwa (KP), Pakistan

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Honokiol: A review of its pharmacological potential and therapeutic insights.

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