机构：[1]Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, & Institute of Digestive Surgery, Sichuan University, Chengdu, 610041, PR China 四川大学华西医院[2]Department of Intensive Care Unit, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, 610041, PR China四川大学华西医院
Aim: To develop nomograms for predicting cancer-specific survival (CSS) and overall survival (OS) in patients with invasive extramammary Paget's disease (iEMPD). Patients & methods: Retrospective data of 1955 patients with iEMPD were collected from the Surveillance, Epidemiology, and End Results database. Nomograms for predicting CSS and OS were established using competing risk regression and Cox regression, respectively, and were internally validated. Results: Five (age, surgery, tumor location, stage and concurrent malignancy) and eight (gender, age, race, marital status, surgery, tumor location, stage and lymph node metastasis) clinicopathological factors were utilized to construct nomograms for predicting CSS and OS, respectively. The concordance indices of the nomograms for predicting CSS and OS were 0.78 and 0.73, respectively. The validation of the nomograms showed good calibration and discrimination. The decision curve analyses confirmed the clinical utility of these nomograms. Conclusion: The nomograms can be a reliable tool for treatment design and prognostic evaluation of iEMPD.
基金：
Sichuan Science and Technology Program (no. 2019YFS0263), Post-Doctoral Research
Project,West China Hospital, Sichuan University (no. 19XJ0075, 2018HXBH007) in the design of the study and collection, analysis,
and interpretation of data and in writing the manuscript.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, & Institute of Digestive Surgery, Sichuan University, Chengdu, 610041, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Gao Xiang,Zhong Xi,Chen Hai-Ning,et al.Nomograms for predicting cancer-specific and overall survival in patients with invasive extramammary Paget's disease.[J].Future oncology (London, England).2021,17(21):2785-2801.doi:10.2217/fon-2021-0372.
APA：
Gao Xiang,Zhong Xi,Chen Hai-Ning,Singh Dujanand,Yang Lie...&Zhou Zong-Guang.(2021).Nomograms for predicting cancer-specific and overall survival in patients with invasive extramammary Paget's disease..Future oncology (London, England),17,(21)
MLA：
Gao Xiang,et al."Nomograms for predicting cancer-specific and overall survival in patients with invasive extramammary Paget's disease.".Future oncology (London, England) 17..21(2021):2785-2801
