机构：[1]Department of Day Surgery Center, West China Hospital, Sichuan University, Chengdu, 610041, China四川大学华西医院[2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China四川大学华西医院[3]Department of Internal Medicine, Chengdu City Jinniu District No. 2 People’s Hospital, Chengdu, 610036, China[4]Department of Gastrointestinal Surgery & Breast & Thyroid Surgery, Minimally Invasive Surgery, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, 610041, China[5]Department of Oncology & Department of Biomedical & Clinical Sciences, Linko¨ ping University, Linko¨ ping, 58183, Sweden
Background: The relationship between long noncoding RNAs (lncRNAs) and the mRNA stemness index (mRNAsi) in colorectal cancer (CRC) is still unclear. Materials & methods: The mRNAsi, mRNAsi-related lncRNAs and their clinical significance were analyzed by bioinformatic approaches in The Cancer Genome Atlas (TCGA)-COREAD dataset. Results: mRNAsi was negatively related to pathological features but positively related to overall survival and recurrence-free survival in CRC. A five mRNAsi-related lncRNAs prognostic signature was further developed and showed independent prognostic factors related to overall survival in CRC patients, due to the five mRNAsi-related lncRNAs involved in several pathways of the cancer stem cells and malignant cancer cell phenotypes. Conclusion: The present study highlights the potential roles of mRNAsi-related lncRNAs as alternative prognostic markers.
基金：
This work was supported by a grant from Sichuan Science and Technology Program (no. 2017JY0061).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Day Surgery Center, West China Hospital, Sichuan University, Chengdu, 610041, China[2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
通讯作者：
通讯机构：[4]Department of Gastrointestinal Surgery & Breast & Thyroid Surgery, Minimally Invasive Surgery, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, 610041, China[5]Department of Oncology & Department of Biomedical & Clinical Sciences, Linko¨ ping University, Linko¨ ping, 58183, Sweden
推荐引用方式(GB/T 7714)：
Wang Xiao-Cheng,Liu Ya,Long Fei-Wu,et al.Identification of a lncRNA prognostic signature-related to stem cell index and its significance in colorectal cancer.[J].Future oncology (London, England).2021,17(23):3087-3100.doi:10.2217/fon-2020-1163.
APA：
Wang Xiao-Cheng,Liu Ya,Long Fei-Wu,Liu Liang-Ren&Fan Chuan-Wen.(2021).Identification of a lncRNA prognostic signature-related to stem cell index and its significance in colorectal cancer..Future oncology (London, England),17,(23)
MLA：
Wang Xiao-Cheng,et al."Identification of a lncRNA prognostic signature-related to stem cell index and its significance in colorectal cancer.".Future oncology (London, England) 17..23(2021):3087-3100
