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Neutrophils-derived Spink7 as one safeguard against experimental murine colitis

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收录情况： ◇ SCIE

作者：
Zhao, N[a] ; Wang, G[a] ; Long, S[a] ; Liu, D[b] ; Gao, J[a] ; Xu, Y[a] ; Wang, C[a] ; Wang, A[a] ; Wang, F[a] ; Hao, Y[a] ; Ran, X[a] ; Wang, J[a] ; Su, Y[a,*1] ; Wang, T[a,*1] ;
机构： [a]Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China [b]Sichuan Cancer Hospital & Institute, Sichuan Cancer Preventive Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, Sichuan 610041, China
出处：
DOI： 10.1016/j.bbadis.2021.166125
ISSN：

关键词： Cytokine Experimental murine colitis Inflammatory bowel disease Neutrophils Spink7

摘要：
The uncontrolled abnormal intestinal immune responses play important role in eliciting inflammatory bowel disease (IBD), yet the molecular events regulating intestinal inflammation during IBD remain poorly understood. Here, we describe an endogenous, homeostatic pattern that controls inflammatory responses in experimental murine colitis. We show that Spink7 (serine peptidase inhibitor, kazal type 7), the ortholog of human SPINK7, is significantly upregulated in dextran sodium sulfate (DSS)-induced murine colitis model. Spink7-deficient mice showed highly susceptible to experimental colitis characterized by enhanced weight loss, shorter colon length, higher disease activity index and increased colonic tissue destruction. Bone marrow reconstitution experiments demonstrated that expression of Spink7 in the immune compartment makes main contribution to its protective role in colitis. What's more, neutrophils are the primary sources of Spink7 in experimental murine colitis. Loss of Spink7 leads to augmented productions of multiple chemokines and cytokines in colitis. In summary, this study identifies neutrophils-derived endogenous Spink7-mediated control of chemokines/cytokines production as a molecular mechanism contributing to inflammation resolution during colitis. © 2021 Elsevier B.V.

基金：
This work was supported by the National Natural Science Foundation of China (Grant No. 81372061 and 81874255 ), and Basic Research Project of Third Military Medical University (Grant No. 2020-2017-106 ).
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外文
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出版当年[2021]版：
大类 | 2 区 生物学
小类 | 1 区 生物物理 2 区 生化与分子生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 生物物理
JCR分区：
出版当年[2021]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 BIOPHYSICS
最新[2023]版：
Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [a]Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China
通讯作者：
通讯机构： [a]Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China [*1]Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China
推荐引用方式(GB/T 7714)：
Zhao N,Wang G,Long S,et al.Neutrophils-derived Spink7 as one safeguard against experimental murine colitis[J].BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE.2021,1867(6):doi:10.1016/j.bbadis.2021.166125.
APA：
Zhao, N,Wang, G,Long, S,Liu, D,Gao, J...&Wang, T.(2021).Neutrophils-derived Spink7 as one safeguard against experimental murine colitis.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1867,(6)
MLA：
Zhao, N,et al."Neutrophils-derived Spink7 as one safeguard against experimental murine colitis".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1867..6(2021)

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