机构：[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院[2]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.[3]Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
The aim of this study is to elucidate the risk of urologic cancers in patients with Crohn's disease (CD) and ulcerative colitis (UC).
Electronic databases including PubMed, the Cochrane Library, Embase and Web of Science, and manual retrieval were conducted from inception to June 2020. Two reviewers independently searched the above databases and selected the studies using prespecified standardized criteria. The Newcastle-Ottawa Scale was used to assess the risk of bias in the included studies, and this meta-analysis was completed by STATA version 14.2.
A total of 12 cohort studies and 4 case-control studies were included in this meta-analysis. Overall, patients with inflammatory bowel disease (IBD) were at significantly increased risk of renal cancer (RCa) [standardized incidence ratio (SIR): 1.53; 95% confidence interval (CI): 1.25-1.80; I2=42.4%], but not at increased risk of prostate cancer (PCa), bladder cancer (BCa) and male genital cancer. In the subgroup analysis, CD patients had a significantly higher RCa risk (SIR: 1.95; 95% CI: 1.45-2.44; I2=39.9%). Besides, CD patients seemed to be at borderline significantly increased risks of PCa (SIR: 1.07; 95% CI: 0.93-1.20; I2=15.1%) and BCa (SIR:1.19; 95% CI: 0.94-1.44; I2=0%), and UC patients seemed to be at borderline significantly increased risks of RCa (SIR:1.31; 95% CI: 0.94-1.67; I2=48.0%) and PCa (SIR: 1.13; 95% CI: 0.93-1.33; I2=73.5%). Notably, we observed that IBD patients in Eastern countries have significantly increased PCa risk (SIR: 2.66; 95% CI: 1.52-3.81; I2=13.6%), especially for UC patients (SIR: 3.01; 95% CI: 1.75-4.27; I2=0.0%).
Our findings indicate that IBD patients with special reference to CD patients increase the risk of RCa. Besides, IBD patients in Asian countries have significantly increased risk of PCa, especially for UC patients. Further studies are warranted to elucidate the potential mechanism of RCa associated with IBD and the differences of the risk of urinary cancers between Eastern and Western countries.
2021 Translational Andrology and Urology. All rights reserved.
基金：
This work was supported by Department
of Science and Technology of Sichuan Province
(2020YFH0099) and the National Natural Science
Foundation of China (No. 81370272, 30901621/C1705).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区男科学4 区泌尿学与肾脏学
最新[2023]版：
大类|3 区医学
小类|4 区男科学4 区泌尿学与肾脏学
第一作者：
第一作者机构：[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.[2]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
共同第一作者：
通讯作者：
通讯机构：[2]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.[3]Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.[*1]Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, Section 3, Renmin Nan Lu, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Feng Dechao,Yang Yubo,Wang Zhenghao,et al.Inflammatory bowel disease and risk of urinary cancers: a systematic review and pooled analysis of population-based studies.[J].Translational andrology and urology.2021,10(3):1332-1341.doi:10.21037/tau-20-1358.
APA：
Feng Dechao,Yang Yubo,Wang Zhenghao,Wei Wuran&Li Li.(2021).Inflammatory bowel disease and risk of urinary cancers: a systematic review and pooled analysis of population-based studies..Translational andrology and urology,10,(3)
MLA：
Feng Dechao,et al."Inflammatory bowel disease and risk of urinary cancers: a systematic review and pooled analysis of population-based studies.".Translational andrology and urology 10..3(2021):1332-1341
