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Regulation of tumor microenvironment for pancreatic cancer therapy.

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机构: [1]Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130021, PR China [2]Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 4, Section 2, Jianshe North Road, Chengdu, 610072, PR China [3]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China [4]State Key Laboratory of Biotherapy and Center, West China Hospital and Collaborative Innovation Center of Biotherapy, Sichuan University, 1# Keyuan Road 4, Gaopeng Street, Chengdu, 610041, PR China
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关键词: Biomaterial Tumor microenvironment Pancreatic cancer Combination therapy Clinical transformation

摘要:
Pancreatic cancer (PC) is one kind of the most lethal malignancies worldwide, owing to its insidious symptoms, early metastases, and negative responses to current therapies. With an increasing understanding of pathology, the tumor microenvironment (TME) plays a significant role in ineffective treatment and poor prognosis of PC. Thus, a growing number of studies have focused on whether components of the TME could be effective targets for PC therapy. Biomaterials have been widely applied in cancer therapy, and numerous organic or inorganic biomaterials for TME regulation have been developed to inhibit the growth and metastasis of PC, as well as reverse therapeutic resistance. In this review, we discuss various biomaterials utilized to treat PC based on different components of the TME, including, but not limited to, extracellular matrix (ECM), abnormal tumor vascularization, and tumor-associated immune cells, as well as other unconventional therapeutic strategies. Besides, the perspectives on the underlying future of theranostic nanomedicines for PC therapy are also presented. Copyright © 2021 Elsevier Ltd. All rights reserved.

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出版当年[2021]版:
大类 | 1 区 工程技术
小类 | 1 区 工程:生物医学 1 区 材料科学:生物材料
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 工程:生物医学 1 区 材料科学:生物材料
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出版当年[2021]版:
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版:
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130021, PR China
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