The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys
机构：[1]Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Center, School of Medicine, Sichuan CancerHospital and Institute, University of Electronic Science and Technology of China, Chengdu, China,四川省肿瘤医院[2]Department of ClinicalLaboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women’s and Children’s Hospitalof Chengdu Medical College, Chengdu, China
The coronavirus disease 2019 (COVID-19) pandemic, induced by the pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly all over the world. There is considerable variability among neonates, children, and adults in the incidence of infection and severe disease following exposure to SARS-CoV-2. In our study, we analyzed the transcriptome data of primate animal model of Rhesus monkeys to evaluate the expression levels of possible SARS-CoV-2 receptors and proteases and immunologic features in the lungs, colons, livers, and brains at different developmental stages. Our results revealed that ACE2 and TMPRSS2 were highly expressed in neonates compared with other populations, which imply the high incidence of infection. Other potential receptors and Type II transmembrane serine proteases (TTSPs) and cathepsin of endosomal proteases also exhibited dynamic and differential expression patterns. The expression of receptors (ACE2, BSG, and DPP4) and proteases (TMPRSS2, TMPRSS9, CTSL, and CTSB) were highly correlated during lung development, suggesting the high susceptibility of the lungs. TMPRSS9 was specifically highly expressed in the lungs and reached the highest level in neonates, similar to TMPRSS2. Moreover, the immune cell infiltration analysis revealed immunity immaturity in neonates, implying the association with the mild or moderate type of COVID-19. The results might help researchers design protective and therapeutic strategies for COVID-19 in populations at different ages.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872402, 81602731]; Science and Technology Department of Sichuan Province [2020YJ0453]
第一作者机构：[1]Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Center, School of Medicine, Sichuan CancerHospital and Institute, University of Electronic Science and Technology of China, Chengdu, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Cao Bangrong,Zhang Liping,Liu Huifen,et al.The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys[J].FRONTIERS IN GENETICS.2021,11:doi:10.3389/fgene.2020.607479.
APA：
Cao, Bangrong,Zhang, Liping,Liu, Huifen,Ma, Shiqi&Mi, Kun.(2021).The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys.FRONTIERS IN GENETICS,11,
MLA：
Cao, Bangrong,et al."The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys".FRONTIERS IN GENETICS 11.(2021)
