机构：[1]Laboratory of Allergy & Inflammation, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.[2]Department of Pulmonary and Critical Care Medicine, Sub-center of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Chongqing Medical University, Chengdu 610031, China.[3]State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Taipa, Macau (SAR), China.[4]Department of Respiratory Disease, Sichuan Friendship Hospital, Chengdu 610000, China.[5]Department of Respiratory Disease, Renshou County People's Hospital, Chengdu 620550, China.
Aim: To elucidate the transcriptional characteristics of COVID-19. Materials & methods: We utilized an integrative approach to comprehensively analyze the transcriptional features of both COVID-19 patients and SARS-CoV-2 infected cells. Results: Widespread infiltration of immune cells was observed. We identified 233 genes that were codifferentially expressed in both bronchoalveolar lavage fluid and lung samples of COVID-19 patients. Functional analysis suggested upregulated genes were related to immune response such as neutrophil activation and antivirus response, while downregulated genes were associated with cell adhesion. Finally, we identified LCN2, STAT1 and UBE2L6 as core genes during SARS-CoV-2 infection. Conclusion: The identification of core genes involved in COVID-19 can provide us with more insights into the molecular features of COVID-19.
基金：
The work was supported by 2019-nCoV tackling project of Chengdu Science and Technology Bureau (2020-YF05-00003-SN), National Natural Science Foundation of China (81970026, 82000029), Health Commission of Sichuan Province (19ZD002), Science
and Technology Department of Sichuan Province (2018JY0380), project of Chengdu high level clinical key specialty
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区医学
小类|3 区遗传学
最新[2023]版：
大类|4 区医学
小类|4 区遗传学
第一作者：
第一作者机构：[1]Laboratory of Allergy & Inflammation, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.[2]Department of Pulmonary and Critical Care Medicine, Sub-center of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Chongqing Medical University, Chengdu 610031, China.
共同第一作者：
通讯作者：
通讯机构：[1]Laboratory of Allergy & Inflammation, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.[2]Department of Pulmonary and Critical Care Medicine, Sub-center of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Chongqing Medical University, Chengdu 610031, China.
推荐引用方式(GB/T 7714)：
Li Guoping,Wang Junyi,He Xiang,et al.An integrative analysis identifying transcriptional features and key genes involved in COVID-19.[J].Epigenomics.2020,12(22):1969-1981.doi:10.2217/epi-2020-0168.
APA：
Li Guoping,Wang Junyi,He Xiang,Zhang Lei,Ran Qin...&Zhu Dong.(2020).An integrative analysis identifying transcriptional features and key genes involved in COVID-19..Epigenomics,12,(22)
MLA：
Li Guoping,et al."An integrative analysis identifying transcriptional features and key genes involved in COVID-19.".Epigenomics 12..22(2020):1969-1981
