机构：[1]Deep-Processing of Fine Flake Graphite Sichuan Province Key Laboratory of Colleges and Universities, Panzhihua University, No. 10, Jichang Road, Panzhihua 617000, Sichuan, P. R. China.[2]Panzhihua Central Hospital, No.34 Yikang street, Panzhihua avenue, Panzhihua, 617000, Sichuan, P. R. China[3]Institute of Biomass Functional Materials Interdisciplinary Studies Jilin Engineering Normal University, No.3050, Kaixuan Road, Changchun 130052, P.R. China
Systems consisting of different functional components that synergistically increase the antitumor efficiency of different cancer therapies are in great demand. Here, we report the use of nanoparticles (NPs) composed of a zwitterionic conjugated polymer, generating reactive oxygen species (ROS) and heat. These NPs are more effective in antitumor than single photodynamic therapy (PDT) or photothermal therapy (PTT) and have an optimal absorbance ranging from 700 to 850 nm. Light in this range is capable of reaching tumors by penetrating deep into tissues. The simultaneous PDT and PTT using a single near-infrared (NIR) light can be monitored via photoacoustic imaging (PAI). Treatment of tumor-bearing nude mice with combined PDT and PTT following tail vein injection of NPs resulted in complete tumor remission. No tumor relapse was observed during a 20 day treatment. These zwitterionic conjugated polymeric NPs with the capability of generating ROS and heat show great potential for PAI-guided photodynamic/photothermal dual-modal therapy.
基金：
National Natural Science Foundation of China (21504088).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区工程技术
小类|3 区材料科学：生物材料
最新[2023]版：
大类|2 区医学
小类|3 区材料科学：生物材料
第一作者：
第一作者机构：[1]Deep-Processing of Fine Flake Graphite Sichuan Province Key Laboratory of Colleges and Universities, Panzhihua University, No. 10, Jichang Road, Panzhihua 617000, Sichuan, P. R. China.
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Zhe,Cao Yue,Zhu Xuejun,et al.Zwitterionic Conjugated Polymer as the Single Component for Photoacoustic-Imaging-Guided Dual-Modal Near-Infrared Phototherapy.[J].ACS biomaterials science & engineering.2020,6(7):4005-4011.doi:10.1021/acsbiomaterials.0c00206.
APA：
Zhang Zhe,Cao Yue,Zhu Xuejun,Li Yufeng&Cai Xiaoyan.(2020).Zwitterionic Conjugated Polymer as the Single Component for Photoacoustic-Imaging-Guided Dual-Modal Near-Infrared Phototherapy..ACS biomaterials science & engineering,6,(7)
MLA：
Zhang Zhe,et al."Zwitterionic Conjugated Polymer as the Single Component for Photoacoustic-Imaging-Guided Dual-Modal Near-Infrared Phototherapy.".ACS biomaterials science & engineering 6..7(2020):4005-4011
