机构：[1]Department of Hepatobiliary Surgery I, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.南方医科大学珠江医院[2]Research Center for Biomedical Optics and Molecular Imaging, Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.[3]Guangdong Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou, 510280, China.[4]Biliary Surgical Department of West China Hospital, Sichuan University, Chengdu, Sichuan, 610064, China.[5]Department of Ultrasound, Shenzhen People's Hospital, The Second Clinical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518020, China.深圳市康宁医院深圳市人民医院深圳医学信息中心中国医科大学附属盛京医院中国医科大学盛京医院
Hypoxia, a prominent hallmark of hepatocellular carcinoma (HCC), undermines curative outcomes, elevates recurrence rates, and fosters metastasis, particularly during photodynamic therapy (PDT) in clinical settings. Studies indicate that alleviating tumor hypoxia can enhance PDT efficacy. However, persistent challenges, including suboptimal oxygen delivery efficiency and absence of real-time feedback on blood oxygen fluctuations during PDT, considerably impede the therapeutic effectiveness in tumor treatment. This study improves PDT efficacy against HCC using near-infrared-II (NIR-II) photoacoustic (PA) imaging for tumor-targeted oxygen delivery and controlled release. For this purpose, a biomimetic oxygen delivery system designated BLICP@O2 is developed, which utilizes hybrid tumor cell membranes and thermosensitive liposomes as oxygen carriers, incorporating the NIR-II dye IR1048, photosensitizer chlorin e6 (Ce6) and perfluorohexane. Upon sequential irradiation at 1064 nm and 690 nm, BLICP@O2 exhibits significant photothermal and photodynamic effects. Photothermal heating triggers oxygen release, thus enhancing the photodynamic effect of Ce6. Blood oxygen changes during PDT are tracked by multispectral PA imaging. Enhanced PDT efficacy, mediated by hypoxia relief, is convincingly demonstrated both in vitro and in vivo. This work presents an imaging-guided strategy for tumor-targeted oxygen delivery and controlled release using dual-wavelength programmed cascaded treatment strategy, and real-time efficacy monitoring using PA imaging, offering valuable insights for overcoming challenges in PDT-based cancer therapy. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
National Key Research and Development Program of China (2021YFE0202200, 2022YFE0132300, 2020YFA0908800, and
2016YFC0106500); National Natural Science Foundation of China
(NSFC) (Grant Nos. 82122034, 92059108, 81927807, 81627805,
12026602, 82172008, and 62105355); the NSFC-GD Union Foundation
(U1401254), Chinese Academy of Sciences Grant (Youth Innovation
Promotion Association 2019352, 2023374, YJKYYQ20190078,
and GJJSTD20210003); Shenzhen Science and Technology Innovation
Grant (JCYJ20220818101403008, JCYJ20200109141222892,
JCYJ20220531100409023, and JCYJ20210324101403010); Biomedical
Imaging Science and System Key Laboratory, Chinese Academy of
Sciences; CAS Key Laboratory of Health Informatics (2011DP173015);
Guangdong Provincial Key Laboratory of Biomedical Optical Imaging
(2020B121201010); Shenzhen Key Laboratory for Molecular Imaging
(ZDSY20130401165820357); and Science and Technology Program of
Guangzhou (2023A04J2415).
第一作者机构：[1]Department of Hepatobiliary Surgery I, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.[2]Research Center for Biomedical Optics and Molecular Imaging, Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.[3]Guangdong Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou, 510280, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hepatobiliary Surgery I, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.[3]Guangdong Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou, 510280, China.
推荐引用方式(GB/T 7714)：
Zeng Silue,Chen Jingqin,Gao Rongkang,et al.Nir-Ii Photoacoustic Imaging-Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma[J].ADVANCED MATERIALS.2024,36(4):doi:10.1002/adma.202308780.
材料科学