机构：[1]National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China[2]College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou 646000, China[3]Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry Chinese Academy of Sciences, Beijing Mass Spectrum Center, Beijing 100190, China
Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.
基金：
Sichuan Administration of traditional Chinese Medicine (2020JC0150), the fellowship
of China Postdoctoral Science Foundation (Grant NO. 2020M683365), the National Natural
Science Foundation of China (NO. 82074378) and the strategic cooperation project of transfer and
transformation of scientific and technological achievements between Luzhou Municipal People’s Government/
Luxian County People’s government and Southwest Medical University (2019LZXNYDC02
and 2019LXXNYKD-01).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|2 区药学
最新[2023]版：
大类|3 区医学
小类|2 区药学
第一作者：
第一作者机构：[1]National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China[2]College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou 646000, China
共同第一作者：
通讯作者：
通讯机构：[1]National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China[2]College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou 646000, China
推荐引用方式(GB/T 7714)：
Liang Pan,Mao Linshen,Dong Yanli,et al.Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy.[J].Pharmaceutics.2021,13(12):doi:10.3390/pharmaceutics13122070.
APA：
Liang Pan,Mao Linshen,Dong Yanli,Zhao Zhenwen,Sun Qin...&Ren Wei.(2021).Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy..Pharmaceutics,13,(12)
MLA：
Liang Pan,et al."Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy.".Pharmaceutics 13..12(2021)
