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Hemecitones A and B: two phenanthrenes with cytotoxicity from Hemerocallis fulva (L.) L

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机构： [a]Department of Traditional Chinese Medicine, Sichuan Cancer Hospital, Chengdu, P.R. China [b]Department of Gynaecology, Sichuan Cancer Hospital, Chengdu, P.R. China [c]Department of Abdominal Oncology, Sichuan Cancer Hospital, Chengdu, P.R. China

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关键词： cytotoxicity Hemecitones A and B Hemerocallis fulva (L ) L phenanthrenes

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Two new phenanthrenes, Hemecitones A and B, were isolated from Hemerocallis fulva (L.) L. Their structures were determined by UV, IR, HR-ESI-MS, 1D and 2D NMR analysis. The in vitro cytotoxic activities of compounds 1 and 2 were studied against breast carcinoma MDA-MB-231, hepatocellular carcinoma HepG2 and lung carcinoma A549 cell lines. And compounds 1 and 2 exhibited anti-proliferative effects against these least one of the three types of cell lines with IC50 ranging from 12.57 ± 2.34 to 31.22 ± 1.36 μM. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

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出版当年[2022]版：

大类 | 3 区化学

小类 | 3 区应用化学 4 区药物化学

最新[2023]版：

大类 | 3 区化学

小类 | 3 区应用化学 4 区药物化学

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出版当年[2022]版：

Q3 CHEMISTRY, APPLIED Q4 CHEMISTRY, MEDICINAL

最新[2023]版：

Q3 CHEMISTRY, APPLIED Q3 CHEMISTRY, MEDICINAL

影响因子： 1.9 最新[2023版] 2.1 最新五年平均 2.2 出版当年[2022版] 2.3 出版当年五年平均 2.488 出版前一年[2021版] 1.9 出版后一年[2023版]

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第一作者机构： [a]Department of Traditional Chinese Medicine, Sichuan Cancer Hospital, Chengdu, P.R. China

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