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Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.

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资源类型：
Pubmed体系：
作者：
Dai Zhi[1] * ; Liu Hui[2] * ; Wang Bei[2] * ; Yang Dong[3] * ; Zhu Yan-Yan[1] ; Yan Huan[2] ; Zhu Pei-Feng[2] ; Liu Ya-Ping[2] ; Chen Hui-Cheng[1] ; Zhao Yun-Li[1] ; Zhao Li-Xing[1] ; Zhao Xu-Dong[3] ; Liu Hai-Yang[2] ; Luo Xiao-Dong[1,2,*1] ;
机构： [1]Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. [2]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China. [3]Laboratory of Animal Tumor Models, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
出处：
DOI： 10.1016/j.ejmech.2020.113068
ISSN：

关键词： Steroidal saponins Structure-activity relationship Tribulosaponin A Glioma stem cells ROS

摘要：
Glioblastoma multiform (GBM) is the highly aggressive brain tumor with poor prognosis. Glioma stem cells (GSCs), small population of cancer cells that exist in GBM tissues, resistant to chemotherapy and radiotherapy and usually driving GBM recurrence, have been developed as effective therapeutic target. Steroidal saponins are one of important resources for anti-tumor agent and may be benefited to selectively clear GSCs. In this report, total of 97 natural steroidal saponins were investigated the relationship among structures/cytotoxicity/selectivity against GSCs, glioma cell lines and human untransformed cells, and revealed that tribulosaponin A was the most potent compound. Further investigation suggested that tribulosaponin A up-regulated the expression of NCF1 and NOX1 to accumulate ROS for triggering apoptosis in GSCs, but not in untransformed cells, and it was further supported by the assay that N-acetyl-l-cysteine (NAC) clearing ROS delayed GSCs apoptosis. Besides, tribulosaponin A damaged GSCs recapturing tumor spheres formation. Copyright © 2020 Elsevier Masson SAS. All rights reserved.

基金：
Yunnan Joint Funds of the National Natural Science Foundation of China (U1802281), the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), the Department of Science and Technology of Yunnan Province (2019FB115), and the National Natural Science Foundation of China (81802976).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 1 区 药物化学
最新[2023]版：
大类 | 2 区 医学
小类 | 1 区 药物化学
第一作者：
第一作者机构： [1]Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. [2]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China. [*1]Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People’s Republic of China.,
推荐引用方式(GB/T 7714)：
Dai Zhi,Liu Hui,Wang Bei,et al.Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.[J].European journal of medicinal chemistry.2021,210:113068.doi:10.1016/j.ejmech.2020.113068.
APA：
Dai Zhi,Liu Hui,Wang Bei,Yang Dong,Zhu Yan-Yan...&Luo Xiao-Dong.(2021).Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A..European journal of medicinal chemistry,210,
MLA：
Dai Zhi,et al."Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.".European journal of medicinal chemistry 210.(2021):113068

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