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Diterpenoids from Torreya grandis and their cytotoxic activities

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资源类型：
Pubmed体系：
作者：
Yang Zongyu[1,2] ; Luo Wanli[1] ; Yang Zaiwen[3] ; Zhang Maosheng[1,2] ; Dong Minjian[1,2] ; Guo Dale[5] ; Gu Juan[6] ; Sun Chengxin[1,2,*1] ; Xiao Shiji[1,2,*1] ;
机构： [1]Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 563000, China [2]Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China [3]Guizhou Huiteng Extraction Technology Application Research Institute Co., Ltd. Zunyi, Guizhou, 563000, China [4]SiChuan Vocational College of Health and Rehabilitation, Zigong, Sichuan, 643000, China [5]State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of, Traditional Chinese Medicine, Chengdu, Sichuan, 611137, China [6]Department of Pharmacy, Affiliated Hospital of Zunyi Medical University, Guizhou, 563003, China
出处：
DOI： 10.1016/j.phytochem.2024.114036
ISSN：

关键词： Torreya grandis Taxaceae Diterpenoids Cytotoxicity Apoptosis HCT 116 HT-29

摘要：
Eight previously undescribed diterpenoids, along with eleven previously reported analogues, were obtained from the supercritical CO2 extracts of Torreya grandis aril. The structures of these compounds were elucidated based on HRESIMS, NMR, ECD, and single-crystal X-ray diffraction data. In the MTT assay, compound 18 exhibited significant inhibitory effects on two human colon cancer cell lines, HT-29 and HCT 116 cells, with IC50 values of 7.37 μM and 6.55 μM, respectively. It was found that compound 18 induced apoptosis and significantly inhibited the migration of HCT 116 colon cancer cells in a concentration-dependent manner.Copyright © 2024 Elsevier Ltd. All rights reserved.

基金：
This study was financially supported by the National Natural Science Foundation of China (82060706), Horizontal Projects with Guizhou Huiteng Extraction Technology Application Research Institute Co., Ltd., the Science and Technology Department Foundation of Guizhou Province (QKHZC[2020]4Y211,Qian Ke He support S 2020(2319)), and ZunShiKeHe 2021-281.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
第一作者：
第一作者机构： [1]Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 563000, China [2]Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 563000, China [2]Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China [*1]Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 563000, China
推荐引用方式(GB/T 7714)：
Yang Zongyu,Luo Wanli,Yang Zaiwen,et al.Diterpenoids from Torreya grandis and their cytotoxic activities[J].Phytochemistry.2024,221:114036.doi:10.1016/j.phytochem.2024.114036.
APA：
Yang Zongyu,Luo Wanli,Yang Zaiwen,Zhang Maosheng,Dong Minjian...&Xiao Shiji.(2024).Diterpenoids from Torreya grandis and their cytotoxic activities.Phytochemistry,221,
MLA：
Yang Zongyu,et al."Diterpenoids from Torreya grandis and their cytotoxic activities".Phytochemistry 221.(2024):114036

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