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Photodynamic Therapy Directed by Three-Photon Active Rigid Plane Organic Photosensitizer.

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机构： [1]Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, 610041, P. R. China. [2]School of Life Science, Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, P. R. China. [3]Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE) &amp [4] Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, 710072, P. R. China. [4]Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P. R. China. [5]Department of Chemistry, University College London, London, WC1H 0AJ, UK. [6]College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, P. R. China. [7]CAS Center for Excellence in Nanoscience, Institute of Intelligent Machines, Chinese Academy of Science, Hefei, 230031, P. R. China.

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关键词： photodynamic therapy reactive oxygen species rigid planar photosensitizers three-photon absorption

摘要：

Multi-photon photosensitizers (PSs) could significantly improve the efficacy of photodynamic therapy due to the long-wavelength favorability for deeper tissue penetration and lower biological damage. However, most studies are limited to single-photon or two-photon PSs at a relatively short-wave excitation window. To overcome this barrier, we rationally design a series of rigid plane compounds with efficient reactive oxygen species (ROS) production in vitro under laser irradiation. Furthermore, the studies show that one of the compounds (U-TsO) could induce rapid multi-types of cell death under three-photon exposure, suggesting a promising clinical outcome in ex vivo 3D multicellular tumor spheroid. This work offers a novel strategy to construct functional materials with competitive multi-photon photodynamic therapy (PDT) outcome. © 2020 Wiley-VCH GmbH.

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出版当年[2021]版：

大类 | 2 区材料科学

小类 | 2 区工程：生物医学 2 区纳米科技 2 区材料科学：生物材料

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区工程：生物医学 2 区材料科学：生物材料 2 区纳米科技

第一作者：

第一作者机构： [1]Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, 610041, P. R. China. [2]School of Life Science, Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, P. R. China.

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通讯作者：

通讯机构： [1]Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, 610041, P. R. China. [2]School of Life Science, Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, P. R. China. [4] Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, 710072, P. R. China. [4]Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P. R. China. [5]Department of Chemistry, University College London, London, WC1H 0AJ, UK.

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Photodynamic Therapy Directed by Three-Photon Active Rigid Plane Organic Photosensitizer.

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