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Plumbagin inhibits the proliferation of nasopharyngeal carcinoma 6-10B cells by upregulation of reactive oxygen species

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li, Baisen[1] * ; Gu, Xiuhui[2] * ; Wu, Mingbo[3] * ; Zhao, Ye[3] * ; Yang, Jie[3] ; Feng, Li[3] ; Gou, Junjie[3] ; Chen, Linyi[3] ; Li, Ting[3] ; Li, Linpeng[3] ; Wang, Lan[3] ; Zhu, Li[4,*2] ; Zhang, Kun[3,*1] ;
机构： [1]Department of Radiation Oncology, School of Medicine, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, University of Electronic Science and Technology of China [2]School of Basic Medical Sciences,Chengdu Medical College, Chengdu, China [3]School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China [4]Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital, Chengdu Medical College, Chengdu, China
出处：
DOI： 10.1097/CAD.0000000000000665
ISSN：

关键词： nasopharyngeal carcinoma plumbagin proliferation reactive oxygen species

摘要：
Plumbagin (PLB) is the primary component of the traditional Chinese medicine Baihua Dan, and possesses anti-infection and anticancer effects, with the ability to enhance the sensitivity of tumor cells to radiation therapy. However, the anticancer effect of PLB on nasopharyngeal carcinoma and the underlying mechanisms remain unclear. In this study, we investigated the anticancer effects of PLB on nasopharyngeal carcinoma 6-10B cells and clarified its molecular mechanisms in vitro. The results showed that PLB was effective against 6-10B cells proliferation in a dose-dependent manner by inducing G2/M phase cell cycle arrest. Furthermore, our data showed that PLB induced reactive oxygen species accumulation, which inhibited the GSK3 beta/STAT3 pathway and arrested the G2/M phase. Therefore, our results provided new insight into the mechanism of the antitumor effects of PLB, supporting PLB as a prospective therapeutic drug in nasopharyngeal carcinoma by modulating intracellular redox balance. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81301919]; Application and Basic Project of Science and Technology Department of Sichuan Province [2016JY0184, 2015JY0256]; Scientific Research Foundation of Health and Family Planning commission of Sichuan Province [17PJ584]; Scientific Research Foundation of the Education Department of Sichuan Province [18ZA0140, 15ZA0257, 15ZA0261]; State Undergraduate Innovative Experiment Program [201713705004, 201713705005, 201713705036]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 药学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 药学
JCR分区：
出版当年[2018]版：
Q3 PHARMACOLOGY & PHARMACY Q4 ONCOLOGY
最新[2023]版：
Q3 ONCOLOGY Q3 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Radiation Oncology, School of Medicine, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, University of Electronic Science and Technology of China
共同第一作者：
通讯作者：
通讯机构： [3]School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China [4]Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital, Chengdu Medical College, Chengdu, China [*1]School of Biological Sciences and Technology, Chengdu Medical College, Chengdu 610500, China [*2]Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital, Chengdu Medical College, Chengdu 610500, China
推荐引用方式(GB/T 7714)：
Li Baisen,Gu Xiuhui,Wu Mingbo,et al.Plumbagin inhibits the proliferation of nasopharyngeal carcinoma 6-10B cells by upregulation of reactive oxygen species[J].ANTI-CANCER DRUGS.2018,29(9):890-897.doi:10.1097/CAD.0000000000000665.
APA：
Li, Baisen,Gu, Xiuhui,Wu, Mingbo,Zhao, Ye,Yang, Jie...&Zhang, Kun.(2018).Plumbagin inhibits the proliferation of nasopharyngeal carcinoma 6-10B cells by upregulation of reactive oxygen species.ANTI-CANCER DRUGS,29,(9)
MLA：
Li, Baisen,et al."Plumbagin inhibits the proliferation of nasopharyngeal carcinoma 6-10B cells by upregulation of reactive oxygen species".ANTI-CANCER DRUGS 29..9(2018):890-897

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