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Positive effects of low-dose photodynamic therapy with aminolevulinic acid or its methyl ester in skin rejuvenation and wound healing: An update

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收录情况： ◇ SCIE

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机构： [1]The Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. [2]Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

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关键词： 5-aminolevulinic acid aging methyl ester aminolevulinate photodynamic therapy reactive oxygen species skin rejuvenation wound healing

摘要：

In dermatology, photodynamic therapy (PDT) is widely used in skin tumors, infections, etc., because of the killing effect triggered by toxic reactive oxygen species (ROS). However, the ROS concentration is determined by various photosensitizer concentrations and formulations, as well as various irradiation parameters. Low-dose PDT leads to sufficiently low ROS level, which results in biological effects that are the exact opposite of the killing potency. Therefore, in recent years, low-dose PDT has been exploited in improving aging and wound. Low-dose ALA/MAL PDT might improve aging through promoting the proliferation of fibroblasts, blocking DNA damage, counteracting oxidative stress, inhibiting melanogenesis, and remodeling lymphatic vessels in aged skin. Promoting fibroblasts and epidermal stem cells proliferation and migration, promoting granulation tissue formation and angiogenesis and regulating the inflammatory process might be the mechanisms of low-dose ALA/MAL PDT in wound healing. Nevertheless, the positive effects of low-dose PDT have not been thoroughly investigated in dermatology, and high-quality studies are still needed to fill the relevant vacancy.© 2023 Wiley-VCH GmbH.

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出版当年[2023]版：

大类 | 3 区物理与天体物理

小类 | 2 区生物物理 3 区生化研究方法 3 区光学

最新[2023]版：

大类 | 3 区物理与天体物理

小类 | 2 区生物物理 3 区生化研究方法 3 区光学

JCR分区：

出版当年[2023]版：

Q3 BIOCHEMICAL RESEARCH METHODS Q3 BIOPHYSICS Q3 OPTICS

最新[2023]版：

Q3 BIOCHEMICAL RESEARCH METHODS Q3 BIOPHYSICS Q3 OPTICS

影响因子： 2 最新[2023版] 2.6 最新五年平均 2 出版当年[2023版] 2.6 出版当年五年平均 2.8 出版前一年[2022版]

第一作者：

第一作者机构： [1]The Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

通讯作者：

通讯机构： [1]The Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. [2]Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. [*1]Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No. 32, Western 2nd Section, 1st Ring Road, Chengdu, Sichuan Province, 610072, China.

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Positive effects of low-dose photodynamic therapy with aminolevulinic acid or its methyl ester in skin rejuvenation and wound healing: An update

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