详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

PCLiON: An Ontology for Data Standardization and Sharing of Prostate Cancer Associated Lifestyles.

文献详情

资源类型：

Pubmed体系：

收录情况： ◇ EI

作者：

机构： [a]Center for Systems Biology, Soochow University, Suzhou, China [b]Department of Medical Informatics, School of Medicine, Nantong University, Nantong, China [c]School of Biotechnology, Suzhou Industrial Park Institute of Services Outsourcing, China [d]Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China [e]Department of Nutrition and Food Science, School of Public Health, Nantong University, Nantong, Jiangsu, China

出处：

DOI：

ISSN：

关键词： Prostate Cancer Lifestyle Risk Factor Ontology Data Standardization

摘要：

Researches on Lifestyle medicine (LM) have emerged in recent years to garner wide attention. Prostate cancer (PCa) could be prevented and treated by positive lifestyles, but the association between lifestyles and PCa is always personalized. In order to solve the heterogeneity and diversity of different data types related to PCa, establish a standardized lifestyle ontology, promote the exchange and sharing of disease lifestyle knowledge, and support text mining and knowledge discovery. The overall construction of PCLiON was created in accordance with the principles and methodology of ontology construction. Following the principles of evidence-based medicine, we screened and integrated the lifestyles and their related attributes. Protégé was used to construct and validate the semantic framework. All annotations in PCLiON were based on SNOMED CT, NCI Thesaurus, the Cochrane Library and FooDB, etc. HTML5 and ASP.NET was used to develop the independent Web page platform and corresponding intelligent terminal application. The PCLiON also uploaded to the National Center for Biomedical Ontology BioPortal. PCLiON integrates 397 lifestyles and lifestyle-related factors associated with PCa, and is the first of its kind for a specific disease. It contains 320 attribute annotations and 11 object attributes. The logical relationship and completeness meet the ontology requirements. Qualitative analysis was carried out for 329 terms in PCLiON, including factors which are protective, risk or associated but functional unclear, etc. PCLiON is publicly available both at http://pcaontology.net/PCaLifeStyleDefault.aspx and https://bioportal.bioontology.org/ontologies/PCALION. Through the bilingual online platforms, complex lifestyle research data can be transformed into standardized, reliable and responsive knowledge, which can promote the shared-decision making (SDM) on lifestyle intervention and assist patients in lifestyle self-management toward the goal of PCa targeted prevention. Copyright © 2020 Elsevier B.V. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 2 区医学

小类 | 2 区计算机：信息系统 2 区卫生保健与服务 3 区医学：信息

最新[2023]版：

大类 | 2 区医学

小类 | 2 区计算机：信息系统 2 区卫生保健与服务 3 区医学：信息

第一作者：

第一作者机构： [a]Center for Systems Biology, Soochow University, Suzhou, China [b]Department of Medical Informatics, School of Medicine, Nantong University, Nantong, China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]PCAO2: an ontology for integration of prostate cancer associated genotypic, phenotypic and lifestyle data [2]PCaLiStDB: a lifestyle database for precision prevention of prostate cancer. [3]Transurethral resection of the prostate is an independent risk factor for biochemical recurrence after radical prostatectomy for prostate cancer. [4]DRT: A new toolbox for the Standard EEG Data Structure in large-scale EEG applications [5]多发性骨髓瘤发生初次化疗近期死亡的临床特点及危险因素分析 [6]Risk Factor Analysis for AKI Including Laboratory Indicators: a Nationwide Multicenter Study of Hospitalized Patients [7]Toxoplasma gondii infection as a risk factor for osteoporosis: a case-control study [8]Patient-reported gastrointestinal symptoms following surgery for gastric cancer and the relative risk factors [9]Will the resection of pheochromocytoma improve preoperative diabetes mellitus? [10]The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma.