机构：[1]Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing[2]Department of Nephrology, Daping Hospital, the Third Military Medical University, Chongqing[3]Department of Nephrology, the First Hospital of Shanxi Medical University, Taiyuan, Shanxi[4]Department of Nephrology, the First Affiliate Hospital of Xinjiang Medical University, Urumqi, Xinjiang[5]Department of Nephrology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou[6]Department of Nephrology, the Jiangsu Province Hospital, Nanjing, Jiangsu江苏省人民医院[7]Department of Nephrology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang[8]Department of Nephrology, Beiijng Freindship Hospital, Capital Medical University, Beijing[9]Department of blood purification, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning[10]Department of Nephrology, Lanzhou University Second hospital, Lanzhou, Gansu[11]Department of Nephrology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shanxi[12]Department of Nephrology, Henan Provincial People’s Hospital, Zhengzhou University, Zhengzhou, Henan[13]Department of Nephrology, China-Japan Friendship Hospital, Beijing[14]Department of Nephrology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang[15]Blood purification center, the First Affiliated Hospital of Xian Jiaotong University, Xi’an[16]Department of Nephrology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning大连医科大学附属第一医院[17]Department of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan四川大学华西医院[18]Department of Nephrology, Shenzhen People’s Hospital, Shenzhen, Guangdong深圳市康宁医院深圳市人民医院深圳医学信息中心[19]Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan[20]Department of Nephrology, the Frist Affiliated Hospital of Anhui Medical university, Hefei, Anhui[21]Department of Nephrology, the Lanzhou Military General Hospital, Lanzhou, Gansu[22]Department of Nephrology, Chenggong Hospital Xiamen University, Xiamen, Fujian[23]Department of Nephrology, the Second Hospital of Jilin University, Changchun, Jilin[24]Department of Nephrology, the Chengdu Military General Hospital, Chengdu, Sichuan[25]Department of Nephrology, the Bethune international peace hospital of PLA, Shijiazhuang, Hebei[26]Department of Nephrology, Ningxia People‘s Hospital, Yinchuan, Ningxia[27]Department of Nephrology, the 306th Hospital of PLA, Beijing[28]Department of Nephrology, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei[29]Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
Background/Aims: Risk factor studies for acute kidney injury (AKI) in China are lacking, especially those regarding non-traditional risk factors, such as laboratory indicators. Methods: All adult patients admitted to 38 tertiary and 22 secondary hospitals in China in any one month between July and December 2014 were surveyed. AKI patients were screened according to the Kidney Disease: Improving Global Outcomes' definition of AKI. Logistic regression was used to analyze the risk factors for AKI, and Cox regression was used to analyze the risk of in-hospital mortality for AKI patients; additionally, a propensity score analysis was used to reconfirm the risk factors among laboratory indicators for mortality. Results: The morbidity of AKI was 0.97%. Independent risk factors for AKI were advancing age, male gender, hypertension, and chronic kidney disease. All-cause mortality was 16.5%. The predictors of mortality in AKI patients were advancing age, tumor, higher uric acid level and increases in Acute Physiologic Assessment and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores. The hazard ratio (HR) for mortality with uric acid levels > 9.1 mg/dl compared with <= 5.2 mg/dl was 1.78 (95% CI: 1.23 to 2.58) for the AKI patients as a group, and was 1.73 (95% CI: 1.24 to 2.42) for a propensity score-matched set. Conclusion: In addition to traditional risk factors, uric acid level is an independent predictor of all-cause mortality after AKI. (c) 2017 The Author(s) Published by S. Karger AG, Basel
基金：
Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z131107002213011]; National Basic Research program of China (973 Program)National Basic Research Program of China [2015CB553605]; Special Fund for NHFPC Scientific Research in the Public Welfare [201502023]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81670694]; Fund of the Chinese PLA 12th Five-Year Plan for Medical Sciences [BWS14J040, BWS11J027]
第一作者机构：[1]Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing
共同第一作者：
通讯作者：
通讯机构：[1]Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing[*1]Department of Nephrology, General Hospital of PLA, Fuxing Road 28, Beijing 100853
推荐引用方式(GB/T 7714)：
Nie Sasa,Feng Zhe,Tang Li,et al.Risk Factor Analysis for AKI Including Laboratory Indicators: a Nationwide Multicenter Study of Hospitalized Patients[J].KIDNEY & BLOOD PRESSURE RESEARCH.2017,42(5):761-773.doi:10.1159/000484234.
APA：
Nie, Sasa,Feng, Zhe,Tang, Li,Wang, Xiaolong,He, Yani...&Chen, Xiangmei.(2017).Risk Factor Analysis for AKI Including Laboratory Indicators: a Nationwide Multicenter Study of Hospitalized Patients.KIDNEY & BLOOD PRESSURE RESEARCH,42,(5)
MLA：
Nie, Sasa,et al."Risk Factor Analysis for AKI Including Laboratory Indicators: a Nationwide Multicenter Study of Hospitalized Patients".KIDNEY & BLOOD PRESSURE RESEARCH 42..5(2017):761-773
