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Role of autophagy in the periodontal ligament reconstruction during orthodontic tooth movement in rats.

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机构： [a]Department of Orthodontics, The Affiliated Stomatology Hospital of Southwest Medical University, Oral & Maxillofacial Reconstruction and Regeneration Laboratory, Southwest Medical University, Luzhou, Sichuan, PR China [b]Department of Oral Diagnostic and Surgical Sciences, Faculty of Dentistry, University of Otago, New Zealand [c]Discipline of Orthodontics, Department of Oral Science, Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand

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关键词： Autophagy Mechanical stress Orthodontic tooth movement Periodontal ligament TNF-a

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Autophagy, a lysosome-based degradation pathway that is reportedly activated by mechanical stress and nutrient deprivation, plays an important role in various physiological and pathological events. The present study investigated the level of autophagy and tumor necrosis factor-α(TNF-α) expression in the periodontal ligaments (PDLs) of Sprague-Dawley (SD) rats to analyze the involvement of autophagy and inflammatory cytokines in orthodontic tooth movement (OTM) and maintaining periodontal tissue homeostasis.SD rats (n = 100) were randomly divided into a control group (n = 10) and an experimental group (n = 90). An orthodontic appliance was placed in each rat in the experimental group, and 10 rats were randomly euthanized 15 min, 30 min, 1 h, 2 h, 4 h, 12 h, 1 d, 3 d and 7 d after mechanical loading. The OTM distance was then measured. Hematoxylin and eosin (HE) staining was used to analyze the morphology of the PDL. Immunohistochemical (IHC) staining and tartrate-resistant acid phosphatase (TRAP) staining were also performed. After the application of orthodontic force and under the dual effects of mechanical force and starvation caused by compressed vessels, the level of autophagy and TNF-α expression in the PDL fluctuated and exhibited a similar trend. Our data suggest a significant correlation between the initiation of autophagy and TNF-α expression, which both exerted positive effects on PDL remodeling during OTM in rats. © 2020 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区牙科与口腔外科

最新[2023]版：

大类 | 3 区医学

小类 | 3 区牙科与口腔外科

第一作者：

第一作者机构： [a]Department of Orthodontics, The Affiliated Stomatology Hospital of Southwest Medical University, Oral & Maxillofacial Reconstruction and Regeneration Laboratory, Southwest Medical University, Luzhou, Sichuan, PR China

通讯作者：

通讯机构： [a]Department of Orthodontics, The Affiliated Stomatology Hospital of Southwest Medical University, Oral & Maxillofacial Reconstruction and Regeneration Laboratory, Southwest Medical University, Luzhou, Sichuan, PR China [*1]Department of Orthodontics, The Affiliated Stomatology Hospital of Southwest Medical University, Oral & Maxillofacial Reconstruction and Regeneration Laboratory, Southwest Medical University, 2 Jiangyang South Road, Luzhou, Sichuan, 646000, PR China

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Role of autophagy in the periodontal ligament reconstruction during orthodontic tooth movement in rats.

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