Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment
机构：[1]Guangzhou Med Univ, Stomatol Hosp, Key Lab Oral Med, Guangzhou Inst Oral Dis, Guangzhou 510140, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[3]Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China;[4]Hlth Time Gene Inst, Shenzhen 518000, Peoples R China
Although long noncoding RNAs (lncRNAs) have been emerging as critical regulators in various tissues and biological processes, little is known about their expression and regulation during the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in inflammatory microenvironment. In this study, we have identified 63 lncRNAs that are not annotated in previous database. These novel lncRNAs were not randomly located in the genome but preferentially located near protein-coding genes related to particular functions and diseases, such as stem cell maintenance and differentiation, development disorders and inflammatory diseases. Moreover, we have identified 650 differentially expressed lncRNAs among different subsets of PDLSCs. Pathway enrichment analysis for neighboring proteincoding genes of these differentially expressed lncRNAs revealed stem cell differentiation related functions. Many of these differentially expressed lncRNAs function as competing endogenous RNAs that regulate protein-coding transcripts through competing shared miRNAs.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31471252, 31771462, 81772614, U1611261]; National Key Research and Development Program [2017YFA0106700]; Guangdong Natural Science FoundationNational Natural Science Foundation of Guangdong Province [2014TQ01R387, 2014A030313181]; Science and Technology Program of Guangzhou, China [201604020003]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
最新[2023]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
第一作者：
第一作者机构：[1]Guangzhou Med Univ, Stomatol Hosp, Key Lab Oral Med, Guangzhou Inst Oral Dis, Guangzhou 510140, Guangdong, Peoples R China;
通讯作者：
通讯机构：[2]Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;[3]Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714)：
Zhang Qingbin,Chen Li,Cui Shiman,et al.Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment[J].SCIENTIFIC REPORTS.2017,7(1):-.doi:10.1038/s41598-017-14451-4.
APA：
Zhang, Qingbin,Chen, Li,Cui, Shiman,Li, Yan,Zhao, Qi...&Ren, Jian.(2017).Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment.SCIENTIFIC REPORTS,7,(1)
MLA：
Zhang, Qingbin,et al."Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment".SCIENTIFIC REPORTS 7..1(2017):-
