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The role of noncoding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

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机构: [1]Educational and Scientific Institute of Neurosurgery, &#x420 [2]eoples' Friendship University of Russia (RUDN University), Moscow, Russia. [2]Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. [3]Department of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, Russia. [4]Republican Clinical Perinatal Center, Ufa, Republic of Bashkortostan, 450106, Russia. [5]Department of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, Russia. [6]Gastric Cancer Center, West China Hospital of Sichuan University, China. [7]Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
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关键词: microRNA Long non-coding RNA Circular RNA Periodontal ligament cell Periodontal ligament stem cell Osteogenic differentiation

摘要:
Human periodontal ligament-derived cells are important seed cells for periodontal regeneration, and their osteogenic potential closely affects alveolar bone repair and periodontal regeneration. Human periodontal ligament stem cells are pluripotent stem cells of mesenchymal origin, which can differentiate in osteoblasts and cementoblasts. However, the molecular mechanism of this differentiation activity is poorly studied. Noncoding RNAs (ncRNAs) belong to RNAs, which do not encode proteins and represent a large segment of the human transcriptome, mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). It was shown that ncRNAs is involved in the proliferation and differentiation of cells, epigenetic modifications, apoptosis, as well as in complex control and pathogenesis of various diseases. NcRNAs are actively involved in the regulation of osteogenic genes in human periodontal ligament-derived cells. This article reviews the research progress of ncRNAs in the regulatory targets, pathways and functions of ncRNAs in the osteogenic differentiation of human periodontal ligament-derived cells.© 2022 The Authors.

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出版当年[2023]版:
大类 | 3 区 生物学
小类 | 3 区 生化与分子生物学
最新[2023]版:
大类 | 3 区 生物学
小类 | 3 区 生化与分子生物学
第一作者:
第一作者机构: [1]Educational and Scientific Institute of Neurosurgery, &#x420 [2]eoples' Friendship University of Russia (RUDN University), Moscow, Russia. [2]Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
通讯作者:
通讯机构: [1]Educational and Scientific Institute of Neurosurgery, &#x420 [*1]Рeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russia.
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