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Glycodendron/pyropheophorbide-a (Ppa)-functionalized hyaluronic acid as a nanosystem for tumor photodynamic therapy.

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Pubmed体系：

收录情况： ◇ EI

作者：
Xiaoqin Zhang[a,b] ; Yahui Wu[a] ; Zhiqian Li[a] ; Wenjia Wang[a] ; Yaping Wu[a] ; Dayi Pan[a] ; Zhongwei Gu[a] ; Ruilong Sheng[d] ; Helena Tomás[d] ; Hu Zhang[c] ; João Rodrigues[d] ; Qiyong Gong[a] ; Kui Luo[a] ;
机构： [a]Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, National Clinical ResearchCenter for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China [b]College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China [c]Amgen Bioprocessing Centre, Keck Graduate Institute, CA 91711, USA [d]CQM - Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390, Funchal, Portugal
出处：
DOI： 10.1016/j.carbpol.2020.116749
ISSN：

关键词： Hyaluronic acid Dendrimer Drug delivery Photodynamic therapy Nanomedicines

摘要：
To enhance the drug delivery efficiency of hyaluronic acid (HA), we designed and prepared glycodendron and pyropheophorbide-a (Ppa)-functionalized HA (HA-Ppa-Dendron) as a nanosystem for cancer photodynamic therapy. Linear Ppa-modified HA (HA-Ppa) was also prepared as a control. Cellular uptake of both polymers by MDA-MB-231 cells led to mitochondrial dysfunction and generation of reactive oxygen species under the irradiation of a laser. Compared to the linear polymer, HA-Ppa-Dendron had higher molecular weight, a more compact nanoscale particle size, and a dendritic structure, resulting in a much longer blood circulation time and higher tumor accumulation. HA-Ppa-Dendron outperformed HA-Ppa in inhibiting cell growth, with 60 % of tumors was eradicated under laser irradiation. Tumor growth inhibition (TGI) up to 99.2 % was achieved from HA-Ppa-Dendron, which was much higher than that of HA-Ppa (50.6 %). Therefore, glycodendron-functionalized HAs by integration of HA and dendritic polymers may act as efficient anti-cancer nanomedicine. Copyright © 2020 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China (51873120, 51673127, 81621003).Ruilong Sheng, Helena Tomás and João Rodrigues appreciate the support from Fundação para a Ciência e a Tecnologia (Base Fund UIDB/00674/2020, CQM, Portuguese Government Funds) and ARDITIAgência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação through the project M1420-01-0145-FEDER-000005-Centro de Química da Madeira-CQM+ (Madeira 14-20 Program) and ARDITI- 2017-ISG-003.
语种：
外文
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出版当年[2020]版：
大类 | 1 区 工程技术
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
最新[2023]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
第一作者：
第一作者机构： [a]Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, National Clinical ResearchCenter for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China [b]College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xiaoqin Zhang,Yahui Wu,Zhiqian Li,et al.Glycodendron/pyropheophorbide-a (Ppa)-functionalized hyaluronic acid as a nanosystem for tumor photodynamic therapy.[J].Carbohydrate polymers.2020,247:116749.doi:10.1016/j.carbpol.2020.116749.
APA：
Xiaoqin Zhang,Yahui Wu,Zhiqian Li,Wenjia Wang,Yaping Wu...&Kui Luo.(2020).Glycodendron/pyropheophorbide-a (Ppa)-functionalized hyaluronic acid as a nanosystem for tumor photodynamic therapy..Carbohydrate polymers,247,
MLA：
Xiaoqin Zhang,et al."Glycodendron/pyropheophorbide-a (Ppa)-functionalized hyaluronic acid as a nanosystem for tumor photodynamic therapy.".Carbohydrate polymers 247.(2020):116749

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