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Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy.

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机构： [1]Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2]Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China [3]Amgen Bioprocessing Centre, Keck Graduate Institute, Claremont, CA 91711, USA

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关键词： Hyaluronic acid Nanomedicines Stimuli-responsive Anti-tumor therapy Drug delivery systems

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Rapid development of stimuli-responsive drug delivery systems (DDSs) for tumor therapy has raised increasing interest in recent decades, and many nanomedicines are prepared to achieve accurate or sustained drug release. However, the fabrication process for these nanomedicines has been far too intricate and their potential biosafety has not been fully understood, which has hampered their clinical translation. Challenges for developing DDSs remain on balancing the complexity of the fabrication process with their translational feasibility. Owing to water-solubility, biocompatibility, biodegradability and CD44-targetability, hyaluronic acid (HA) as a versatile building block has gained great popularity due to a simplified fabrication process and unique characteristics of HA for DDSs. In this review, we overviewed the biological function and multiple chemical modifications of HA, and discussed the fabrication of HA-based drug delivery systems (HA-DDSs) with specific tumor microenvironmental stimuli-responsive linkers. We systemically surveyed the applications of HA-DDSs for chemotherapy, photothermal therapy, photodynamic therapy, immunotherapy, gene delivery and combination therapy.Copyright © 2022. Published by Elsevier Ltd.

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出版当年[2022]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区高分子科学 1 区有机化学

最新[2023]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

第一作者：

第一作者机构： [1]Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

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通讯机构： [1]Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2]Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China [*1]Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu 610041, China

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Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy.

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