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Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy.

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资源类型：
Pubmed体系：
作者：
Hou Xingyu[1] ; Zhong Dan[1] ; Chen Hongying[1] ; Gu Zhongwei[1,2] ; Gong Qiyong[1,2] ; Ma Xuelei[1] ; Zhang Hu[3] ; Zhu Hongyan[1] ; Luo Kui[1,2,*1] ;
机构： [1]Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2]Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China [3]Amgen Bioprocessing Centre, Keck Graduate Institute, Claremont, CA 91711, USA
出处：
DOI： 10.1016/j.carbpol.2022.119662
ISSN：

关键词： Hyaluronic acid Nanomedicines Stimuli-responsive Anti-tumor therapy Drug delivery systems

摘要：
Rapid development of stimuli-responsive drug delivery systems (DDSs) for tumor therapy has raised increasing interest in recent decades, and many nanomedicines are prepared to achieve accurate or sustained drug release. However, the fabrication process for these nanomedicines has been far too intricate and their potential biosafety has not been fully understood, which has hampered their clinical translation. Challenges for developing DDSs remain on balancing the complexity of the fabrication process with their translational feasibility. Owing to water-solubility, biocompatibility, biodegradability and CD44-targetability, hyaluronic acid (HA) as a versatile building block has gained great popularity due to a simplified fabrication process and unique characteristics of HA for DDSs. In this review, we overviewed the biological function and multiple chemical modifications of HA, and discussed the fabrication of HA-based drug delivery systems (HA-DDSs) with specific tumor microenvironmental stimuli-responsive linkers. We systemically surveyed the applications of HA-DDSs for chemotherapy, photothermal therapy, photodynamic therapy, immunotherapy, gene delivery and combination therapy.Copyright © 2022. Published by Elsevier Ltd.

基金：
This work was supported by National Natural Science Foundation of China (51873120, 52003176, 52073193 and 81621003), 1‧3‧5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYJC21013, ZYGD20007 and ZYJC18011).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 高分子科学 1 区 有机化学
最新[2023]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
第一作者：
第一作者机构： [1]Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
共同第一作者：
通讯作者：
通讯机构： [1]Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2]Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China [*1]Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Hou Xingyu,Zhong Dan,Chen Hongying,et al.Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy.[J].Carbohydrate polymers.2022,292:119662.doi:10.1016/j.carbpol.2022.119662.
APA：
Hou Xingyu,Zhong Dan,Chen Hongying,Gu Zhongwei,Gong Qiyong...&Luo Kui.(2022).Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy..Carbohydrate polymers,292,
MLA：
Hou Xingyu,et al."Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy.".Carbohydrate polymers 292.(2022):119662

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