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Dendron-Functionalized Polyglutamate-Pyropheophorbide-a Conjugates as Nanomedicines for Breast Cancer Photodynamic Therapy.

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机构: [1]Huaxi MR Research Center (HMRRC) Department of Radiology Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital Sichuan University Chengdu 610041, China [2]School of Chemistry and Chemical Engineering Mianyang Normal University Mianyang 621000, China [3]Department of Applied Chemistry Faculty of Science Sichuan Agricultural University Yaan 625014, China [4]Amgen Bioprocessing Centre Keck Graduate Institute Claremont, CA 91711, USA
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关键词: cancer therapies dendrimers nanomedicines photodynamic therapies polyglutamic acids

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Photodynamic therapy (PDT) has shown its promise in the treatment of cancer. Herein, a dendron-functionalized polyglutamic acid (PGA) polymer (PG-L8G-Ppa-Dendron, PGPD) is synthesized and it is conjugated with pyropheophorbide-a (Ppa) for the first time to treat triple negative breast cancer (TNBC), whereas a linear polyglutamate-Ppa conjugate (PGP) is synthesized as a control. Compared to the linear counterpart, the glycosylated polymer-based PGPD with a dendritic structure has excellent solubility and it self-assembles to form uniform-sized nanoparticles. PGPD displays a highly effective PDT effect in the animal model, evidenced with effective induction of reactive oxygen species (ROS) production and cell apoptosis. This may be due to an enhanced efficiency in delivery and accumulation of Ppa by this glycosylated dendritic polymer at tumor sites. Therefore, PGPD can be a highly effective and biosafe nanoagent for PDT of TNBC. © 2021 Wiley-VCH GmbH.

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出版当年[2021]版:
大类 | 3 区 化学
小类 | 2 区 高分子科学
最新[2023]版:
大类 | 3 区 化学
小类 | 3 区 高分子科学
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第一作者机构: [1]Huaxi MR Research Center (HMRRC) Department of Radiology Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital Sichuan University Chengdu 610041, China
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