Comparison of postoperative CT- and preoperative MRI-based breast tumor bed contours in prone position for radiotherapy after breast-conserving surgery.
机构：[1]School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China[2]Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan 250117, Shandong, China[3]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China四川大学华西医院[4]Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China[5]Department of Surgical Ward 1, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
To compare the target volume of tumor bed defined by postoperative computed tomography (post-CT) in prone position registered with or without preoperative magnetic resonance imaging (pre-MRI).
A total of 22 patients were included with early-stage breast invasive ductal cancer, who have undergone breast-conservative surgery and received the pre-MRI and post-CT in prone position. The MRI sequences (T1W, T2W, T2W-SPAIR, DWI, dyn-eTHRIVE, sdyn-eTHRIVE) were delineated and manually registered to CT, respectively. The clinical target volumes (CTVs) and planning target volumes (PTVs) were contoured on CT and different MRI sequences, respectively. Differences were measured in terms of consistence index (CI), dice coefficient (DC), geographical miss index (GMI), and normal tissue index (NTI).
The differences of delineation volumes among CT and MRIs were significant, both in the CTVs (p = 0.035) and PTVs (p < 0.001). The values of CI and DC for sdyn-eTHRIVE registration to CT were the largest among all MRI sequences, but GMI and NTI were the smallest. No obvious linear correlation (p > 0.05) between the CI derived from the registration of CT and sdyn-eTHRIVE of CTV with the breast volume, the cavity visualization score (CVS) of CT, time interval from surgery to CT simulation, the maximum diameter of the intraoperative mass, and the number of titanium clips, respectively.
The CTVs and PTVs in MRI sequences were all smaller than those in CT. The pre-MRI, especially the sdyn-eTHRIVE, could be used to optimize the post-CT-based target delineation of breast cancer.
• Registered pre-MRI to post-CT in order to improve the accuracy of target volume delineation of breast cancer. • The CTVs and PTVs in MRI sequences were all smaller than those in CT. • The sdyn-eTHRIVE of pre-MRIs may be a better choice to improve the delineation of CT-based CTV and PTV.
基金：
This study has received funding from the National
Natural Science Foundation of China (No. 81773232), the Academic
promotion program of Shandong First Medical University (No.
2020RC002), and the Foundation of Young Taishan Scholars Program
(No. tsqn201909187).
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外文
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出版当年[2021]版：
大类|2 区医学
小类|2 区核医学
最新[2023]版：
大类|2 区医学
小类|2 区核医学
第一作者：
第一作者机构：[1]School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China[2]Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan 250117, Shandong, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Dong Yinping,Liu Yang,Chen Jinhu,et al.Comparison of postoperative CT- and preoperative MRI-based breast tumor bed contours in prone position for radiotherapy after breast-conserving surgery.[J].European radiology.2021,31(1):345-355.doi:10.1007/s00330-020-07085-0.
APA：
Dong Yinping,Liu Yang,Chen Jinhu,Li Wanhu,Li Yongqing...&Huang Wei.(2021).Comparison of postoperative CT- and preoperative MRI-based breast tumor bed contours in prone position for radiotherapy after breast-conserving surgery..European radiology,31,(1)
MLA：
Dong Yinping,et al."Comparison of postoperative CT- and preoperative MRI-based breast tumor bed contours in prone position for radiotherapy after breast-conserving surgery.".European radiology 31..1(2021):345-355
医学