机构：[1]Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[2]West China Medical School, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu, 610041, Chengdu, China四川大学华西医院[3]Center for Biomedical Engineering, NE47-379, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA
Nanofiber scaffolds formed by self-assembling peptide RADA16-I have been used for the study of cell proliferation to mimic an extracellular matrix. In this study, we investigated the effect of RADA16-I on the growth of human leukemia cells in vitro and in nude mice. Self-assembly assessment showed that RADA16-I molecules have excellent self-assembling ability to form stable nanofibers. MTT assay displayed that RADA16-I has no cytotoxicity for leukemia cells and human umbilical vein endothelial cells (HUVECs) in vitro. However, RADA16-I inhibited the growth of K562 tumors in nude mice. Furthermore, we found RADA16-I inhibited vascular tube-formation by HUVECs in vitro. Our data suggested that nanofiber scaffolds formed by RADA16-I could change tumor microenvironments, and inhibit the growth of tumors. The study helps to encourage further design of self-assembling systems for cancer therapy.
基金：
“project 985” of Ministry of Education of the People’s Republic of China.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类|4 区化学
小类|4 区化学综合
最新[2023]版：
大类|2 区生物学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, China
通讯作者：
通讯机构：[1]Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, China[2]West China Medical School, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu, 610041, Chengdu, China[3]Center for Biomedical Engineering, NE47-379, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA
推荐引用方式(GB/T 7714)：
Tang Chengkang,Shao Ximing,Sun Binbin,et al.The effect of self-assembling peptide RADA16-I on the growth of human leukemia cells in vitro and in nude mice.[J].International journal of molecular sciences.2009,10(5):2136-45.doi:10.3390/ijms10052136.
APA：
Tang Chengkang,Shao Ximing,Sun Binbin,Huang Wenli&Zhao Xiaojun.(2009).The effect of self-assembling peptide RADA16-I on the growth of human leukemia cells in vitro and in nude mice..International journal of molecular sciences,10,(5)
MLA：
Tang Chengkang,et al."The effect of self-assembling peptide RADA16-I on the growth of human leukemia cells in vitro and in nude mice.".International journal of molecular sciences 10..5(2009):2136-45
