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Targeting calcium signaling in cancer therapy

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收录情况： ◇ 统计源期刊 ◇ CSCD-C

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机构： [1]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China; [2]Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China; [3]Ohio State Univ, Dept Surg, Div Thorac Dis, Columbus, OH 43210 USA; [4]Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA; [5]Univ Texas Arlington, Coll Nursing & Hlth Innovat, LS Bldg 239,501 S Nedderman Dr, Arlington, TX 76019 USA

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关键词： Ca2+ channels Store-operated Ca2+ entry Cell proliferation Migration Apoptosis Channel blockers Cancer therapy

摘要：

The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca2+ homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca2+ signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca2+ channels, transporters and Ca2+-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca2+ channels/transporters or Ca2+-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research

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大类 | 1 区

医学

小类 | 1 区药学

第一作者：

第一作者机构： [1]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China; [2]Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China; [3]Ohio State Univ, Dept Surg, Div Thorac Dis, Columbus, OH 43210 USA;

通讯作者：

通讯机构： [3]Ohio State Univ, Dept Surg, Div Thorac Dis, Columbus, OH 43210 USA; [4]Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA; [5]Univ Texas Arlington, Coll Nursing & Hlth Innovat, LS Bldg 239,501 S Nedderman Dr, Arlington, TX 76019 USA

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