Influence of a self-assembling peptide, RADA16, compared with collagen I and Matrigel on the malignant phenotype of human breast-cancer cells in 3D cultures and in vivo.
机构：[1]Institute for Nano-biomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[2]Center for Biomedical Engineering NE47-378, Massachusetts Institute of Technology, 500 Technology Square, Main Street, Cambridge, MA 02139-4307, USA[3]State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China四川大学华西医院
Cancer-cell phenotype is not only the result of malignant progression, but also dependent on the microenvironment surrounding them, including influences from the extracellular matrix and its structural properties. We have investigated the influence of the nanofiber matrix of the self-assembling peptide, RADA16, in comparison with collagen I and Matrigel on the malignant phenotype of the human breast-cancer cell, MDA-MB-231, in 3D cultures, including the morphology, survival, proliferation rate, migration potential and the effect of these matrices on the malignancy of the cancer cells in vivo. Our data indicate that these tumor cells change their morphology in response to the different 3D matrix in vitro cultures and the RADA16 self-assembling peptide scaffold mimics an extracellular matrix and could effectively reduce the malignant phenotype of the tumor cells in vitro and in vivo.
基金：
Chinese National ‘985 Project’ of Education Ministry to Sichuan
University, Chengdu, China
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类|3 区生物
小类|2 区材料科学：生物材料2 区高分子科学3 区生化与分子生物学
最新[2023]版：
大类|4 区医学
小类|2 区高分子科学4 区生化与分子生物学4 区材料科学：生物材料
第一作者：
第一作者机构：[1]Institute for Nano-biomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
通讯作者：
通讯机构：[1]Institute for Nano-biomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.[2]Center for Biomedical Engineering NE47-378, Massachusetts Institute of Technology, 500 Technology Square, Main Street, Cambridge, MA 02139-4307, USA
推荐引用方式(GB/T 7714)：
Mi Kun,Wang Guixia,Liu Zijia,et al.Influence of a self-assembling peptide, RADA16, compared with collagen I and Matrigel on the malignant phenotype of human breast-cancer cells in 3D cultures and in vivo.[J].Macromolecular bioscience.2009,9(5):437-43.doi:10.1002/mabi.200800262.
APA：
Mi Kun,Wang Guixia,Liu Zijia,Feng Zhihua,Huang Ben&Zhao Xiaojun.(2009).Influence of a self-assembling peptide, RADA16, compared with collagen I and Matrigel on the malignant phenotype of human breast-cancer cells in 3D cultures and in vivo..Macromolecular bioscience,9,(5)
MLA：
Mi Kun,et al."Influence of a self-assembling peptide, RADA16, compared with collagen I and Matrigel on the malignant phenotype of human breast-cancer cells in 3D cultures and in vivo.".Macromolecular bioscience 9..5(2009):437-43
