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Association between two genetic variants of CD226 gene and Cervical Squamous Cell Carcinoma: a case-control study.

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机构: [1]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China [2]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, PR China [3]Department of Forensic biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, PR China
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关键词: Cervical Squamous Cell Carcinoma (CSCC) CD226 gene Genetic polymorphisms

摘要:
Cervical carcinoma is a common gynecologic tumor severely influencing the health and life quality of women worldwide. CD226, a costimulatory molecule, is mainly participated in the activation and differentiation of T cells. Recent studies have investigated the association between two genetic variants (rs763361 and rs727088) of CD226 gene and many diseases. In order to evaluate whether these two variants are associated with Cervical Squamous Cell Carcinoma (CSCC), a case-control study including 349 CSCC patients and 380 unrelated healthy controls was carried out to determine the genotypes of these two variants by using the methods of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. Significantly increased CSCC risk was observed to be associated with G allele of rs727088 locus (OR=1.422, 95% CI=1.129-1.792). We have also observed that increased CSCC risk was statistically associated with rs727088 polymorphism in a dominant model (OR=1.41, 95% CI=1.05-1.89). Results of stratified analysis revealed that both rs763361 and rs727088 polymorphisms were not associated with clinical characters. Collectively, this study supports that rs727088 polymorphism may contribute to increased CSCC susceptibility. Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved.

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出版当年[2013]版:
大类 | 4 区 生物
小类 | 4 区 遗传学
最新[2023]版:
大类 | 3 区 生物学
小类 | 3 区 遗传学
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第一作者机构: [1]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China
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通讯机构: [1]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China [2]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, PR China [*1]Department of Immunology,West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China
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