机构：[1]Laboratory of Early Developmental and Injuries,West China Institute of Woman and Children’s Health,West China Second University Hospital, Sichuan University, Chengdu, China[2]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, China[3]Department of Pediatrics,West China Second University Hospital, Sichuan University, Chengdu, China[4]Department of Laboratory Medicine, West China Hospital,Sichuan University, Chengdu, China四川大学华西医院
The ubiquitin-proteasome system (UPS) regulates many cellular processes, including protein stability, cell cycle control, DNA repair, transcription, signal transduction, and protein trafficking. In fact, UPS plays a key role in various stress conditions such as ischemia, glutamate toxicity, Alzheimer's disease, and Parkinson's disease. Huwe1, a homologous to E6-AP carboxy terminus (HECT) domain ubiquitin ligase, is now being regarded as a vital protein involved in neural stem cell differentiation, adult neurogenesis, and the DNA damage response pathway. In response to DNA damage, Huwe1 may have a dual function in arresting DNA replication and in ending checkpoint signaling. The proliferation and differentiation of neural stem cells regulated by Huwe1-mediated Notch signaling could also play an important role in neural protection following neural injury. Considering Huwe1 is required for neural precursor survival and the regulation of the DNA damage response pathway, there is growing evidence and considerable hope that Huwe1 might be a therapeutic target for neural injury.
基金：
National Natural Science Foundation of China (#0973215), Sichuan Province Science and Technology Foundation (#2012SZ0010), and the Program of Changjiang Scholars and Innovative Research Team in University (IRT0935).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区生物
小类|4 区生化与分子生物学4 区遗传学
最新[2023]版：
无
第一作者：
第一作者机构：[4]Department of Laboratory Medicine, West China Hospital,Sichuan University, Chengdu, China
通讯作者：
通讯机构：[1]Laboratory of Early Developmental and Injuries,West China Institute of Woman and Children’s Health,West China Second University Hospital, Sichuan University, Chengdu, China[2]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, China
推荐引用方式(GB/T 7714)：
Zhou J,Liu Q,Mao M,et al.Huwe1 as a therapeutic target for neural injury.[J].Genetics and molecular research : GMR.2014,13(2):4320-5.doi:10.4238/2014.June.9.18.
APA：
Zhou J,Liu Q,Mao M&Tong Y.(2014).Huwe1 as a therapeutic target for neural injury..Genetics and molecular research : GMR,13,(2)
MLA：
Zhou J,et al."Huwe1 as a therapeutic target for neural injury.".Genetics and molecular research : GMR 13..2(2014):4320-5
