机构：[1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 64 Medical Center Drive, PO Box 9196, Morgantown, WV 26506-9196, USA[2]Department of Pediatric Orthopaedics, Shandong Provincial Hospital afliated to Shandong First Medical University, Jinan, China[3]Department of Orthopaedics, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China[4]WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA
Due to poor self-regenerative potential of articular cartilage, stem cell-based regeneration becomes a hopeful approach for the treatment of articular cartilage defects. Recent studies indicate that neural crest-derived cells (NCDCs) have the potential for repairing articular cartilage with even greater chondrogenic capacity than mesoderm-derived cells (MDCs): a conventional stem cell source for cartilage regeneration. Given that NCDCs originate from a different germ layer in the early embryo compared with MDCs that give rise to articular cartilage, a mystery remains regarding their capacity for articular cartilage regeneration. In this review, we summarize the similarities and differences between MDCs and NCDCs including articular and nasal chondrocytes in cell origin, anatomy, and chondrogenic differentiation and propose that NCDCs might be promising cell origins for articular cartilage regeneration.
基金：
This work was supported by Research Grants from the Musculoskeletal Transplant Foundation (MTF) and the National Institutes
of Health (1R01AR067747) to M.P., China Scholarship Council
(201909370041) and National Natural Science Foundation of China
(81501844) to T.Y.L., and Health Commission of Sichuan Province
(18PJ008), Science & Technology Department of Sichuan Province (2019YFS0267) and National Natural Science Foundation of China
(81601889) to S.C.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|2 区生物学
小类|2 区生化与分子生物学2 区细胞生物学
最新[2023]版：
大类|2 区生物学
小类|2 区生化与分子生物学2 区细胞生物学
第一作者：
第一作者机构：[1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 64 Medical Center Drive, PO Box 9196, Morgantown, WV 26506-9196, USA[2]Department of Pediatric Orthopaedics, Shandong Provincial Hospital afliated to Shandong First Medical University, Jinan, China
共同第一作者：
通讯作者：
通讯机构：[1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 64 Medical Center Drive, PO Box 9196, Morgantown, WV 26506-9196, USA[4]WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA
推荐引用方式(GB/T 7714)：
Li Tianyou,Chen Song,Pei Ming.Contribution of neural crest-derived stem cells and nasal chondrocytes to articular cartilage regeneration.[J].Cellular and molecular life sciences : CMLS.2020,77(23):4847-4859.doi:10.1007/s00018-020-03567-y.
APA：
Li Tianyou,Chen Song&Pei Ming.(2020).Contribution of neural crest-derived stem cells and nasal chondrocytes to articular cartilage regeneration..Cellular and molecular life sciences : CMLS,77,(23)
MLA：
Li Tianyou,et al."Contribution of neural crest-derived stem cells and nasal chondrocytes to articular cartilage regeneration.".Cellular and molecular life sciences : CMLS 77..23(2020):4847-4859
：
生物学