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Role of Notch signaling pathway in pancreatic cancer.

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机构： [1]Sichuan College of Tranditional Chinese Medicine, Mianyang, Sichuan, China [2]Department of Infectious Diseases, Mianyang 404 Hospital, Mianyang, Sichuan, China [3]The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215123, China [4]Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA

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Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United States. It has been shown that multiple signaling pathways are involved in the pathogenesis of PC, such as JNK, PI3K/AKT, Rho GTPase, Hedgehog (Hh) and Skp2. In recent years, accumulated evidence has demonstrated that Notch signaling pathway plays critical roles in the development and progression of PC. Therefore, in this review we discuss the recent literature regarding the function and regulation of Notch in the pathogenesis of PC. Moreover, we describe that Notch signaling pathway could be down-regulated by its inhibitors or natural compounds, which could be a novel approach for the treatment of PC patients.

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出版当年[2017]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Sichuan College of Tranditional Chinese Medicine, Mianyang, Sichuan, China

通讯作者：

通讯机构： [3]The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215123, China [4]Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA [*1]De-partment of Pathology, Beth Israel Deaconess Medi- cal Center, Harvard Medical School, 330 Brookline Ave., CLS 628B, Boston, MA 02215, USA.

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