机构：[1]Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China四川大学华西医院[2]Department of Surgery, Vrinnevi Hospital, Norrko¨ping, Sweden[3]Laboratory of Stem Cell Biology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China四川大学华西医院[4]Department of Oncology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China四川大学华西医院[5]Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linko¨ping University, Country Council of O¨stergo¨tland, Linko¨ping, Sweden
Currently, little is known regarding the role of peroxisome proliferator-activated receptor-β (PPAR β) in the vascular endothelial cells (VECs) of colorectal cancers (CRCs). The aim of this study was to investigate the relationship of PPAR β expression in the VECs of CRCs in terms of the prognosis and clinicopathological features of CRC patients.
The expression and localization of PPAR β in the primary cancers and the matched normal mucosal samples of 141 Swedish CRC patients were analyzed in terms of its correlation with clinicopathological features and the expression of angiogenesis-related genes. This study also included 92 Chinese CRC patients.
PPAR β was predominantly localized in the cytoplasm and was significantly downregulated in the VECs of CRC compared to that of the normal mucosa. The low expression levels of PPAR β in the VECs of CRC were statistically correlated with enhanced differentiation, early staging and favorable overall survival and were associated with the increased expression of VEGF and D2-40. The patients exhibiting elevated expression of PPAR β in CRC cells but reduced expression in VECs exhibited more favorable survival compared with the other patients, whereas the patients with reduced expression of PPAR β in CRC cells but increased expression in VECs exhibited less favorable prognosis.
PPAR β might play a tumor suppressor role in CRC cells in contrast to a tumor promoter role in the VECs of CRCs.
基金：
This study was supported by grants from the
Natural Science Foundation of China (Grant No. 30801332), the
Specialized Research Fund for the Doctoral Program of Higher
Education of China (Grant No. 200806100058), the Foundation for
the Author of National Excellent Doctoral Dissertation of PR China
(No. 2007B66), and the Swedish Cancer Foundation, Swedish
Research Council and the Health Research Council in the South-East
of Sweden.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区医学
小类|2 区胃肠肝病学
最新[2023]版：
大类|2 区医学
小类|2 区胃肠肝病学
第一作者：
第一作者机构：[1]Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China[5]Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linko¨ping University, Country Council of O¨stergo¨tland, Linko¨ping, Sweden
推荐引用方式(GB/T 7714)：
Zhou Jin,Yang Lie,Li Yuan,et al.The prognostic significance of peroxisome proliferator-activated receptor β expression in the vascular endothelial cells of colorectal cancer.[J].Journal of gastroenterology.2014,49(3):436-45.doi:10.1007/s00535-013-0845-7.
APA：
Zhou Jin,Yang Lie,Li Yuan,Arbman Gunnar,Chen Ke-Ling...&Sun Xiao-Feng.(2014).The prognostic significance of peroxisome proliferator-activated receptor β expression in the vascular endothelial cells of colorectal cancer..Journal of gastroenterology,49,(3)
MLA：
Zhou Jin,et al."The prognostic significance of peroxisome proliferator-activated receptor β expression in the vascular endothelial cells of colorectal cancer.".Journal of gastroenterology 49..3(2014):436-45
