机构：[1]Department of Neurosurgery, Zhujiang Hospital, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Southern Medical University, Guangzhou 510282, China[2]Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China[3]Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China[4]Department of Neurosurgery, The First Affiliated Hospital of Jinan University, 613 West Huangpu Road, Guangzhou 510630, China
Histone deacetylases (HDACs) play a role in the tumorigenesis of glioblastoma multiforme (GBM), whereas the underlying mechanism has not been elucidated. Here, we reported significantly higher HDAC6 levels in GBM from the patients. GBM cell growth was significantly inhibited by ACY-1215, a specific HDAC6 inhibitor. Further analyses show that HDAC6 may promote growth of GBM cells through inhibition of SMAD2 phosphorylation to downregulate p21. Thus, our data demonstrate a previously unrecognized regulation pathway in that HDAC6 increases GBM growth through attenuating transforming growth factor β (TGFβ) receptor signaling.
第一作者机构：[1]Department of Neurosurgery, Zhujiang Hospital, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Southern Medical University, Guangzhou 510282, China[2]Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Zhujiang Hospital, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Southern Medical University, Guangzhou 510282, China[4]Department of Neurosurgery, The First Affiliated Hospital of Jinan University, 613 West Huangpu Road, Guangzhou 510630, China
推荐引用方式(GB/T 7714)：
Li Shun,Liu Xiao,Chen Xiangrong,et al.Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling.[J].TUMOR BIOLOGY.2015,36(12):9661-9665.doi:10.1007/s13277-015-3747-x.
APA：
Li Shun,Liu Xiao,Chen Xiangrong,Zhang Liu&Wang Xiangyu.(2015).Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling..TUMOR BIOLOGY,36,(12)
MLA：
Li Shun,et al."Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling.".TUMOR BIOLOGY 36..12(2015):9661-9665
