机构：[1]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[2]Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming 650500, Yunnan, People’s Republic of China[3]Department of Orthopedics, National Clinical Key Specialty, Yanan Hospital, Kunming Medical University, Kunming 650051, Yunnan, People’s Republic of China[4]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[5]Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[6]Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China
IL-12 is an antitumor cytokine with functions of inhibiting tumor growth, invasion, and metastasis, indicating that IL-12 is a promising candidate for cancer treatment. The aim of this study was to investigate the association of IL-12A rs568408, IL-12A rs2243115, and IL-12B rs3212227 with the susceptibility to colorectal cancer (CRC). Two hundred and fifty-seven histopathologically confirmed CRC patients and 236 age- and gender-matched controls were enrolled. The three polymorphisms were genotyped using a polymerase chain reaction-restriction fragment length polymorphism assay. We found that the IL-12A rs568408 AG/AA genotypes were associated with an increased risk of CRC with an adjusted odds ratio (OR) of 1.66 (95 % confidence interval (CI), 1.11-2.48). Stratified analyses showed that patients carrying the IL-12B rs3212227AC/CC genotypes had a 1.97-fold increased risk of tumor metastasis (OR = 1.97; 95 % CI, 1.04-3.70). Gene-gene interaction analysis showed that subjects carrying the IL-12A rs568408AG/AA and IL-12B rs3212227AA genotypes had a 2.40-fold increased risk of CRC (OR = 2.40; 95 % CI, 1.14-5.07) and individuals carrying the IL-12A rs568408AG/AA and IL-12B rs3212227AC/CC genotypes had a 1.93-fold increased risk of CRC (OR = 1.93; 95 % CI, 1.10-3.41). These findings indicate that IL-12A rs568408 and IL-12B rs3212227 may be related to the development of CRC.
基金：
This study was funded by the National Natural Science Foundation of China (Nos. 81302149 and 81202387), the Ph.D. Programs
Foundation of Ministry of Education of China (No. 20130181120011),
Distinguished Young Scientist o f Sichuan University (No.
2013SCU04A38), and the Science & Technology Pillar Program of Sichuan Province (Nos. 2014SZ0001 and 2013JY0013)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[2]Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming 650500, Yunnan, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[4]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[5]Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China
推荐引用方式(GB/T 7714)：
Sun Ruifen,Jia Fu,Liang Yundan,et al.Interaction analysis of IL-12A and IL-12B polymorphisms with the risk of colorectal cancer.[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.2015,36(12):9295-301.doi:10.1007/s13277-015-3685-7.
APA：
Sun Ruifen,Jia Fu,Liang Yundan,Li Lijuan,Bai Peng...&Zhang Lin.(2015).Interaction analysis of IL-12A and IL-12B polymorphisms with the risk of colorectal cancer..Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,36,(12)
MLA：
Sun Ruifen,et al."Interaction analysis of IL-12A and IL-12B polymorphisms with the risk of colorectal cancer.".Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 36..12(2015):9295-301
