机构：[1]Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China[2]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China[3]Department of Orthopedics, National Clinical Key Specialty, Yanan Hospital, Kunming Medical University, Kunming 650051, Yunnan, People’s Republic of China[4]Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China[5]Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China
A long ncRNA (lncRNA) prostate cancer non-coding RNA 1 (PRNCR1) in the 8q24 has been reported to be upregulated in prostate cancer with a function of activating androgen receptor (AR). AR plays a key role in the gender disparity, cell migration, and invasion of gastric cancer (GC). We hypothesized that single nucleotide polymorphisms (SNPs) in the lncRNA PRNCR1 may be related to the risk of GC. We conducted a case-control study to investigate the association between SNPs in the lncRNA PRNCR1 and the risk of GC. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used to determine the genotypes of 613 subjects including 219 cases with GC and 394 controls. We found that patients with the rs13252298AG genotype displayed a 1.50-fold increased risk of GC (AG vs. AA, 95 % confidence interval (CI) = 1.05-2.12, p = 0.02). Interestingly, the rs7007694CT and CC and the rs1456315GG genotypes displayed a decreased risk of GC (rs7007694CT vs. TT, odds ratio (OR) = 0.68, 95 % CI = 0.48-0.97, p = 0.03; rs7007694CC vs. TT, OR = 0.36, 95 % CI = 0.13-0.97, p = 0.04; rs1456315GG vs. AA, OR = 0.30, 95 % CI = 0.13-0.70, p = 0.004, respectively). Our results suggest that SNPs in the lncRNA PRNCR1 may be a biomarker for the etiology of GC.
基金：
This work was supported by the National Natural
Science Foundation of China (no. 81302149 and 81202387), Distinguished Young Scientist of Sichuan University (no. 2013SCU04A38),
the Science and Technology Pillar Program of Sichuan Province
(2014KJT059-2014SZ0001), and the PhD Programs Foundation of the
Ministry of Education of China (no. 20130181120011).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China[2]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China
通讯作者：
通讯机构：[2]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China[5]Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China
推荐引用方式(GB/T 7714)：
Li Lijuan,Jia Fu,Bai Peng,et al.Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer.[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.2016,37(1):299-303.doi:10.1007/s13277-015-3750-2.
APA：
Li Lijuan,Jia Fu,Bai Peng,Liang Yundan,Sun Ruifen...&Gao Linbo.(2016).Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer..Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,37,(1)
MLA：
Li Lijuan,et al."Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer.".Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 37..1(2016):299-303
