机构：[1]Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu, Sichuan, PR China,[2]Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, PR China,[3]Department of Health Care, Chengdu Wenjiang District Maternal and Child Health Hospital, Chengdu, Sichuan, PR China[4]Department of Intestinal Surgery, Sichuan Cancer Hospital, Sichuan, PR China四川省肿瘤医院
Background and aim: Insulin resistance (IR) is an established risk factor for colorectal cancer (CRC) and both IR and CRC physiologically overlap. As such, this study explored the relationship of IR-related gene polymorphisms and CRC risk. Subjects and methods: A total of 400 case-control pairs were profiled in terms of their lifestyle, dietary habits and blood sample. Classification and regression tree (CART) and generalized multi-factor dimensionality reduction (GMDR) were employed to test the gene-environment interactions in CRC risk. Results: ADIPOQ rs2241766 TG + GG, ADIPOQ rs1501299 GT + TT and CAPN-10 rs3792267 GA + AA were significantly related to CRC risk. In CART, individuals with high red meat consumption, CAPN-10 rs3792267 GG, ADIPOQ rs1501299 GG and ADIPOQ rs2241766 TG + GG had an OR of 1.821 (95% CI = 1.124-2.951). The overall best GMDR model including the four factors had the maximal TBA (0.5943) and CVC (10/10) (p = 0.0010). Subjects with high red meat consumption and the three risk genotypes had a CRC risk 10.195-times (95% CI = 2.164-48.030) greater than those with low red meat and null risk genotypes. Conclusions: ADIPOQ rs2241766, ADIPOQ rs1501299 and CAPN-10 rs3792267 are significantly associated with CRC risk and the combination of the three polymorphisms and red meat affect CRC risk.
基金：
The study was supported by the Doctoral Fund of Ministry of
Education of China (Grant number 20090181120019) and the National
Natural Science Foundation of China (Grant number 81102196).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区生物
小类|4 区生物学4 区公共卫生、环境卫生与职业卫生
最新[2023]版：
大类|4 区医学
小类|4 区人类学4 区生物学4 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2015]版：
Q2BIOLOGYQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTHQ2ANTHROPOLOGYQ3PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q2ANTHROPOLOGYQ3BIOLOGYQ4PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu, Sichuan, PR China,[2]Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, PR China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu, Sichuan, PR China,[*1]Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu, Sichuan, PR China.
推荐引用方式(GB/T 7714)：
Xiaoqin Hu,Fei Feng,Xiaoling Li,et al.Gene polymorphisms related to insulin resistance and gene-environment interaction in colorectal cancer risk[J].ANNALS OF HUMAN BIOLOGY.2015,42(6):560-568.doi:10.3109/03014460.2014.1002532.
APA：
Xiaoqin Hu,Fei Feng,Xiaoling Li,Ping Yuan,Rongsheng Luan...&Yanfang Yang.(2015).Gene polymorphisms related to insulin resistance and gene-environment interaction in colorectal cancer risk.ANNALS OF HUMAN BIOLOGY,42,(6)
MLA：
Xiaoqin Hu,et al."Gene polymorphisms related to insulin resistance and gene-environment interaction in colorectal cancer risk".ANNALS OF HUMAN BIOLOGY 42..6(2015):560-568
