机构：[1]Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research for Cancer, Tianjin, 300060 China.[2]Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060 China.[3]Tianjin's Clinical Research Center for Cancer, Tianjin, 300060 China.[4]Department of Anesthesiology, Tangshan People's Hospital, Hebei, 063001 China.[5]Sichuan Provincial Hospital for Women and Children, Chengdu, Sichuan, 610000 China.[6]School of Biomedical Engineering, Tianjin Medical University, Tianjin, 300070 China.[7]Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, 300070 China.[8]Tianjin Research Institute of Anesthesiology, Tianjin, 300070 China.[9]Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong.
Ketamine is one of general anesthetics and has been commonly used in obstetric and pediatric anesthesia. However, effects of exposure to ketamine on neonatal brain are largely unknown. In this study, we aim to investigate the effect of neonatal exposure of ketamine on spatial memory and long-term potentiation (LTP) in the hippocampus of adult rats. One-week-old neonatal rats were separated into ketamine group and control group. Neonatal rats in ketamine group were received intraperitoneal injection of 25 mg/kg (low-dose group, N = 8) or 50 mg/kg ketamine (high-dose group, N = 8). Neonatal Rats in control group received saline injection (N = 8). After 10 weeks, the spatial memory of adult rats was examined by using Morris Water Maze, and LTP in the hippocampus of adult rats was assessed by electrophysiological experiment. We found that exposure of ketamine to neonatal rats, either low-dose or high-dose, had not induced alteration on their adulthood's escape latency, swimming speed and the percentage of time spent in original quadrant compared with the control. The electrophysiological examination showed that the induction of LTP in hippocampus was significantly reduced in adult rats of ketamine group (either low-dose or high-dose). Our study showed that neonatal exposure of ketamine inhibited the induction of hippocampal LTP without impairing the spatial memory of adult rats.
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外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区工程技术
小类|4 区神经科学
最新[2023]版：
大类|3 区工程技术
小类|3 区神经科学
第一作者：
第一作者机构：[1]Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research for Cancer, Tianjin, 300060 China.[2]Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060 China.[3]Tianjin's Clinical Research Center for Cancer, Tianjin, 300060 China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research for Cancer, Tianjin, 300060 China.[2]Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060 China.[3]Tianjin's Clinical Research Center for Cancer, Tianjin, 300060 China.
推荐引用方式(GB/T 7714)：
Guo Dongyong,Gan Jianhui,Tan Tao,et al.Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats.[J].Cognitive neurodynamics.2018,12(4):377-383.doi:10.1007/s11571-018-9474-4.
APA：
Guo Dongyong,Gan Jianhui,Tan Tao,Tian Xin,Wang Guolin&Ng Kevin Tak-Pan.(2018).Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats..Cognitive neurodynamics,12,(4)
MLA：
Guo Dongyong,et al."Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats.".Cognitive neurodynamics 12..4(2018):377-383
