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Alkoxy Tetrazine Substitution at a Boron Center: A Strategy for Synthesizing Highly Fluorogenic Hydrophilic Probes.

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机构: [1]Huaxi MR Research Center (HMRRC) Department of Radiology, West China Hospital West China Medical School, Sichuan University 001 Forth Keyuan Road, 610041, Chengdu (P.R. China) [2]Department of Nuclear Medicine, West China Hospital Sichuan University, Sichuan 610041 (P.R. China) [3]Institute of Clinical Trials, West China Hospital Sichuan University, Chengdu, Sichuan 610041 (P.R. China)
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关键词: bioorthogonal chemistry dyes/pigments fluorescent probes imaging agents tetrazines

摘要:
Strongly fluorogenic boron dipyrromethene (BODIPY)-tetrazine probes have been obtained by introducing an alkoxy tetrazine fragment at the boron center. The fluorescence signal from these probes strongly increases by up to 225-fold after reaction with bioorthogonal coupling partners, and the hydrophilicity of probes is improved, such that they are suitable for live-cell imaging. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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出版当年[2018]版:
大类 | 3 区 生物
小类 | 3 区 生化与分子生物学 3 区 药物化学
最新[2025]版:
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 药物化学
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第一作者机构: [1]Huaxi MR Research Center (HMRRC) Department of Radiology, West China Hospital West China Medical School, Sichuan University 001 Forth Keyuan Road, 610041, Chengdu (P.R. China)
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