高级检索
当前位置: 首页 > 详情页

A novel triarylboron based ratiometric fluorescent probe for in vivo targeting and specific imaging of cancer cells expressing abnormal concentration of GGT.

文献详情

资源类型:
Pubmed体系:

收录情况: ◇ EI

机构: [a]Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College & Department of Chemistry, School of Preclinical Medicine, North Sichuan Medical College, Nanchong, 637000, China [b]Key Laboratory of Photochemistry, Institute of Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100190, China [c]Department of Radiology, Affiliated Hospital of North Sichuan Medical College, China
出处:
ISSN:

关键词: Fluorescence Triarylboron GGT Ovarian cancers Targeting

摘要:
Abnormal expression of γ-glutamyltranspeptidase (GGT) in living organisms is closely associated with tumorigenesis. However, few reported fluorescence probes can specifically respond to abnormal concentration of GGT. Here, by functionalizing triarylboron moiety with three GGT-specific substrate (GSH) units, a novel fluorescence probe, TAB-3-GSH, was developed for detecting GGT. The results showed that TAB-3-GSH selectively responds to abnormally high levels of GGT (100-1000 U/L) rather than to normal GGT levels (<100 U/L) with ratiometric readout, since the amide linkage can be further hydrolyzed under high GGT levels. TAB-3-GSH was also capable of differentiating GGT-overexpressing ovarian cancer cells from normal cells, because of an improvement in the probe's cell membrane permeability upon reaction with GGT. Moreover, the probe could achieve selective imaging of SKOV-3 tumor site in xenograft mice model. Thus, TAB-3-GSH is a promising probe for tumor targeting in vivo. Copyright © 2019 Elsevier B.V. All rights reserved.

基金:
语种:
PubmedID:
中科院(CAS)分区:
出版当年[2019]版:
大类 | 1 区 化学
小类 | 1 区 生物物理 1 区 生物工程与应用微生物 1 区 分析化学 1 区 电化学 1 区 纳米科技
最新[2023]版:
大类 | 1 区 生物学
小类 | 1 区 生物物理 1 区 生物工程与应用微生物 1 区 分析化学 1 区 电化学 2 区 纳米科技
第一作者:
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:43390 今日访问量:1 总访问量:3121 更新日期:2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持:重庆聚合科技有限公司 地址:成都市人民南路四段55号