机构：[1]Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University[2]Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University[3]Department of Integrated Traditional Chinese and Western Medicine, West China Medical School, Sichuan University[4]Mathematical College, Sichuan University, Chengdu, Sichuan 610041, P.R. China
The future of personalized cancer treatments relies on the development of functional agents that have tumor-targeted anticancer activities and can be detected in tumors using imaging. However, application of these functional agents in the clinic has been limited due to inefficient drug delivery, low specificity for tumor imaging, development of drug resistance, low signal-to-noise ratio and safety concerns regarding potential toxicity. Currently, the most common strategy to develop these functional agents is to conjugate therapeutic agents with the appropriate fluorescent probe. The present study synthesized a novel mitochondria-targeted heptamethine cyanine (Cy) derivative Cy‑triphenylphosphonium. The newly developed compound exhibited stronger near infrared (NIR) fluorescence and reacted with bovine serum albumin. In addition, it preferentially accumulated in the mitochondria of cancer cells, as observed using confocal microscopy, and efficiently reduced cancer cell viability (IC50=3.04 µM). This novel multifunctional heptamethine Cy derivative, with cancer mitochondria targeting and NIR fluorescence imaging, may be promising as an alternative anticancer agent.
基金：
China National '12.5' Foundation [2011BAJ07B04]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [20972105]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学
最新[2023]版：
大类|3 区医学
小类|4 区医学：研究与实验4 区肿瘤学
第一作者：
第一作者机构：[1]Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University
共同第一作者：
通讯作者：
通讯机构：[1]Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University[4]Mathematical College, Sichuan University, Chengdu, Sichuan 610041, P.R. China[*1]Institute for Nanobiomedical Technology and Membrane Biology, Laboratory of Ethnopharmacology, West China Medical School, Sichuan University, 1 Keyuan Road 4, Chengdu, Sichuan 610041, P.R. China[*2]Mathematical College, Sichuan University, 1 Keyuan Road 4, Chengdu, Sichuan 610041, P.R. China
推荐引用方式(GB/T 7714)：
Ning Juewei,Huang Baozhan,Wei Zeliang,et al.Mitochondria targeting and near-infrared fluorescence imaging of a novel heptamethine cyanine anticancer agent.[J].Molecular medicine reports.2017,15(6):3761-3766.doi:10.3892/mmr.2017.6451.
APA：
Ning Juewei,Huang Baozhan,Wei Zeliang,Li Wen'en,Zheng Huajie...&Huang Wen.(2017).Mitochondria targeting and near-infrared fluorescence imaging of a novel heptamethine cyanine anticancer agent..Molecular medicine reports,15,(6)
MLA：
Ning Juewei,et al."Mitochondria targeting and near-infrared fluorescence imaging of a novel heptamethine cyanine anticancer agent.".Molecular medicine reports 15..6(2017):3761-3766
