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A triarylboron-based fluorescent probe with activatable photosensitivity for imaging mitoDNA

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机构: [1]School of Pharmacy and School of Pharmacy and Institute of Pharmacy, Medical Imaging Key Laboratory of Sichuan Province, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Sichuan, 637100, China. [2]Pharmacy Department, Langzhong People's Hospital, Sichuan, 637400, China. [3]Physical-Technical Institute, Uzbekistan Academy of Sciences, 100084, Tashkent, Uzbekistan [4]Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
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关键词: Mitochondria DNA Tumor cell detection Photodynamic therapy Triarylboron compound Fluorescence probe

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The accurate differentiation between tumor cells and normal cells in a rapid, sensitive, and quantitative manner is essential for ensuring effective cancer diagnosis and treatment. In this study, two triaryboron (TAB)-based fluorescent probes, namely TAB-6-B and TAB-4-B, were synthesized by introducing multiple cationic pyridine groups onto TAB structures, and these probes were subsequently employed for the selective imaging of mitochondrial DNA (mitoDNA). Both probes exhibited significant fluorescence enhancement effects in response to DNA, albeit with varying degrees of enhancement and blue shift. TAB-4-B exhibited a higher selectivity toward DNA than TAB-6-B, with longer DNA strands leading to a stronger fluorescence intensity after binding to TAB-4-B. The photosensitivity of TAB-4-B was significantly enhanced when combined with DNA. Moreover, since DNA can be oxidized by reactive oxygen species, the photosensitivity of TAB-4-B can be exploited to induce DNA damage. It was also found that TAB-4-B exhibited a significantly stronger fluorescence signal in tumor cells than in normal cells, thereby facilitating the distinction between tumor and normal cells. Furthermore, it was confirmed that TAB-4-B could locate the mitochondria and induce tumor cell apoptosis under low-intensity visible light irradiation (1.2 mW/cm2). These results indicate the potential of TAB-4-B for use in applications ranging from cancer diagnosis to guiding tumor photodynamic therapy.Copyright © 2025 Elsevier B.V. All rights reserved.

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出版当年[2025]版:
大类 | 2 区 化学
小类 | 2 区 分析化学
最新[2025]版:
大类 | 2 区 化学
小类 | 2 区 分析化学
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第一作者机构: [1]School of Pharmacy and School of Pharmacy and Institute of Pharmacy, Medical Imaging Key Laboratory of Sichuan Province, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Sichuan, 637100, China.
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