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Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao).

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Pubmed体系：

收录情况： ◇ EI

作者：
Yan Liang[a,b,c,d] * ; Xiong Chuan[d] ; Xu Pan[a] ; Zhu Jing[b,c,d] ; Yang Zhirong[e] ; Ren Hong[a] ; Luo Qiang[a] ;
机构： [a]Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Chinese Ministry of Education, Department of Infectious Diseases, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China [b]Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China [c]China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400014, China [d]Chongqing key laboratory of pediatrics, Chongqing, 400014, China [e]Sichuan Province Key Laboratory of Nature Resources Microbiology and Technique, College of Life Sciences, Sichuan University, Chengdu, 610064, China
出处：
DOI： 10.1016/j.carbpol.2019.02.081
ISSN：

关键词： Artemisia annua L Huang Huahao Polysaccharide Antitumor activity Apoptosis Nuclear factor-κB (NF-κB) p65

摘要：
One water-soluble polysaccharide (AAP), with a molecular weight of 6.3 × 104 Da, was isolated from Artemisia annua L. Structrual analysis indicated that AAP was found to be a 1, 3-α-linked and 1, 3, 6-α-linked Glcp backbone, with a branch of 1, 6-α-linked Glcp and terminal 1-linked-L-Rhap along the main chain in a ratio of 1: 1: 1: 1. MTT assay showed that AAP reduced the cell viability of HepG2 cells in a concentration-dependent manner. DAPI staining and Flow cytometric analysis revealed that AAP suppressed cells proliferation, not most at least via inducing p65-dependent mitochondrial signaling pathway, as evidenced by more activation of caspase-3 and -9, down-regulation of Bcl-2 protein, up-regulation of Bax protein and release of cytochrome c from mitochondria into cytosol, as well as suppression of the nuclear factor-κB (NF-κB) p65. These data confirmed AAP inhibits HepG2 cell growth via inducing caspase-dependent mitochondrial apoptosis and inhibition of NF-κB p65. Copyright © 2019 Elsevier Ltd. All rights reserved.

基金：
Chongqing Postdoctoral Science Special Foundation (Grant No: XmT2018076)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 工程技术
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
最新[2023]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
第一作者：
第一作者机构： [a]Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Chinese Ministry of Education, Department of Infectious Diseases, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China [b]Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China [c]China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400014, China [d]Chongqing key laboratory of pediatrics, Chongqing, 400014, China
通讯作者：
推荐引用方式(GB/T 7714)：
Yan Liang,Xiong Chuan,Xu Pan,et al.Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao).[J].Carbohydrate polymers.2019,213:361-369.doi:10.1016/j.carbpol.2019.02.081.
APA：
Yan Liang,Xiong Chuan,Xu Pan,Zhu Jing,Yang Zhirong...&Luo Qiang.(2019).Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao)..Carbohydrate polymers,213,
MLA：
Yan Liang,et al."Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao).".Carbohydrate polymers 213.(2019):361-369

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