Coexpression modules constructed by weighted gene co-expression network analysis indicate ubiquitin-mediated proteolysis as a potential biomarker of uveal melanoma.
机构：[1]Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530031[2]Department of Ophthalmology, The People's Hospital of Leshan, Leshan, Sichuan 614000[3]Department of Radiotherapy,Xuzhou Central Hospital Affiliated to Nanjing University of Chinese Medicine[4]Department of Radiotherapy, Xuzhou Hospital Affiliated to The Medical College of Southeast University[5]Department of Radiotherapy, Xuzhou Clinical School[6]Department of Radiotherapy, Cancer Institute, Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China
Uveal melanoma (UM) is a tumor that affects individuals throughout the world. Although gene expression analysis of UM has been performed previously, systemic co-expression analysis for this type of cancer remains lacking. Microarray data of UM samples was obtained from the Genome Expression Omnibus (dataset GSE44295). Co-expression modules were built by weighted gene co-expression network analysis. Functional enrichment analysis was performed on the co-expressed genes from important modules. Seven co-expression modules were constructed from the 5,000 genes gathered from the 58 human UM samples. The number of genes in these modules ranged from 73 to 3,051, with the mean number being 711. There was a marked difference in interactions among pairwise modules. Functional enrichment analysis demonstrated that module 2 was mainly enriched in pathways associated with the regulation of transcription. Additionally, modules 2-4 were significantly enriched in the ubiquitin mediated proteolysis pathway, suggesting it could serve a critical role in the occurrence and development of UM. The findings of the present study present a framework of co-expressed gene modules for human UM and provide an improved understanding of these modules at a functional level. Understanding the molecular mechanism and cellular pathways involved in pathogenesis of UM is extremely important for the development of more effective diagnostic and therapeutic strategies.
基金：
uveal melanoma, co-expression, modules, gene expression, function
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530031
共同第一作者：
通讯作者：
通讯机构：[1]Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530031[3]Department of Radiotherapy,Xuzhou Central Hospital Affiliated to Nanjing University of Chinese Medicine[4]Department of Radiotherapy, Xuzhou Hospital Affiliated to The Medical College of Southeast University[5]Department of Radiotherapy, Xuzhou Clinical School[6]Department of Radiotherapy, Cancer Institute, Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China[*1]Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, 13 Dancun Road, Nanning, Guangxi 530031, P.R. China[*2]Department of Radiotherapy, Xuzhou Central Hospital Affiliated to Nanjing University of Chinese Medicine, 199 South Road, Xuzhou, Jiangsu 221009, P.R. China
推荐引用方式(GB/T 7714)：
Yang Meng,Wan Qi,Hu Xiang,et al.Coexpression modules constructed by weighted gene co-expression network analysis indicate ubiquitin-mediated proteolysis as a potential biomarker of uveal melanoma.[J].Experimental and therapeutic medicine.2019,17(1):237-243.doi:10.3892/etm.2018.6945.
APA：
Yang Meng,Wan Qi,Hu Xiang,Yin Haitao,Hao Dawei...&Li Jianmin.(2019).Coexpression modules constructed by weighted gene co-expression network analysis indicate ubiquitin-mediated proteolysis as a potential biomarker of uveal melanoma..Experimental and therapeutic medicine,17,(1)
MLA：
Yang Meng,et al."Coexpression modules constructed by weighted gene co-expression network analysis indicate ubiquitin-mediated proteolysis as a potential biomarker of uveal melanoma.".Experimental and therapeutic medicine 17..1(2019):237-243
