机构：[1]Department of Endocrinology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China[2]Winship Cancer Institute, School of Medicine, Emory University, Atlanta, Georgia 30322, USA[3]Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China[4]Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA[5]Department of Pathology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA[6]State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, Sichuan Province, China
Rapid advances in nanomedicine have significantly changed many aspects of nanoparticle application to the eye including areas of diagnosis, imaging and more importantly drug delivery. The nanoparticle-based drug delivery systems has provided a solution to various drug solubility-related problems in ophthalmology treatment. Nanostructured compounds could be used to achieve local ocular delivery with minimal unwanted systematic side effects produced by taking advantage of the phagocyte system. In addition, the in vivo control release by nanomaterials encapsulated drugs provides prolong exposure of the compound in the body. Furthermore, certain nanoparticles can overcome important body barriers including the blood-retinal barrier as well as the corneal-retinal barrier of the eye for effective delivery of the drug. In summary, the nanotechnology based drug delivery system may serve as an important tool for uveal melanoma treatment.
基金：
Supported by the National Natural Science
Foundation of China (No. 81201808, No. 81502544); the
American Fight For Sight Postdoctoral Award; Central South
University Lieying grant; Emory University Melanoma
Prevention and Research Discovery Fund; an unrestricted
grant from Research to Prevent Blindness, Inc.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|4 区医学
小类|4 区眼科学
最新[2023]版：
大类|4 区医学
小类|4 区眼科学
第一作者：
第一作者机构：[1]Department of Endocrinology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China[2]Winship Cancer Institute, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
通讯作者：
通讯机构：[3]Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China[4]Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA[*1]Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
推荐引用方式(GB/T 7714)：
You Shuo,Luo Jing,Grossniklaus Hans E,et al.Nanomedicine in the application of uveal melanoma.[J].International Journal of Ophthalmology.2016,9(8):1215-25.doi:10.18240/ijo.2016.08.20.
APA：
You Shuo,Luo Jing,Grossniklaus Hans E,Gou Ma-Ling,Meng Ke&Zhang Qing.(2016).Nanomedicine in the application of uveal melanoma..International Journal of Ophthalmology,9,(8)
MLA：
You Shuo,et al."Nanomedicine in the application of uveal melanoma.".International Journal of Ophthalmology 9..8(2016):1215-25
