机构：[1]Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China[2]Department of Medicine and Division of Gastroenterology and Hepatology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA[3]Department of Gastroenterology, Southwest Hospital, Army Medical University, Chongqing 400038, China[4]Department of Endoscopy, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China[5]Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China[6]Department of Gastroenterology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China[7]Department of Gastroenterology, The Second Affiliated Hospital, Guangxi Medical University, Nanning 530000, China[8]Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Laterally spreading tumor (LST) is a type of precancerous lesion of colorectal cancer with high malignant potential. The present study aimed to evaluate long-term outcomes of endoscopic treatment for LST in Chinese patients.
This study was a retrospective review of data collected from 653 included patients with LST from six regional representative hospitals in China between January 2007 and January 2017. Demographic characteristics, endoscopic features of LST, operation-related data, and follow-up results were collected and analyzed.
LST-granular type (LST-G, 80.3%) was much more common than LST-non-grandular type (LST-NG, 19.7%). The overall submucosal invasion rate of all LSTs was 6.1% and the submucosal invasion rate of LST-NG was significantly higher than that of LST-G (6.79% vs. 3.87%, p = 0.000). The en bloc resection rate of ESD and EMR treatment was 96% and 93.7%, respectively, with pathologic R0 resection rate of 90.1% and 82.8%. After an average duration of follow-up about 34.52 ± 11.76 months, the recurrence rate of ESD was 3.47%, and the recurrence rate of EMR was 8.8% after an average follow-up of about 38.44 ± 4.42 months. However, the recurrence rate of ESD was much lower than piecemeal EMR for LST (3.47% vs. 8.62%, p = 0.017). Retroflexion-assisted technique applied for resection of rectal LST was associated with a significantly shortened operating time (85.40 min vs. 174.18 min, p = 0.002).
Endoscopic resection is a safe and efficient modality for the treatment of colorectal LST with a relatively low recurrence rate and shortened operating time with the use of retroflexion.
基金：
We want to express our gratitude to the Science
and Technology Planning Project of Guangdong Province
(2017A020215139). Guangdong gastrointestinal disease research
center (No. 2017B020209003).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区医学
小类|2 区外科
最新[2023]版：
大类|2 区医学
小类|2 区外科
第一作者：
第一作者机构：[1]Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China[2]Department of Medicine and Division of Gastroenterology and Hepatology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China[8]Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
推荐引用方式(GB/T 7714)：
Yue Li,Yue Zhang,Yao Chen,et al.Long-term outcomes of endoscopic treatment for colorectal laterally spreading tumor: a large-scale multicenter retrospective study from China.[J].Surgical endoscopy.2021,35(2):736-744.doi:10.1007/s00464-020-07440-8.
APA：
Yue Li,Yue Zhang,Yao Chen,Yusi Wang,Lizhou Dou...&Side Liu.(2021).Long-term outcomes of endoscopic treatment for colorectal laterally spreading tumor: a large-scale multicenter retrospective study from China..Surgical endoscopy,35,(2)
MLA：
Yue Li,et al."Long-term outcomes of endoscopic treatment for colorectal laterally spreading tumor: a large-scale multicenter retrospective study from China.".Surgical endoscopy 35..2(2021):736-744
医学