机构：[1]School of Pharmacy, Southwest Medical University, Luzhou 646000, China.[2]Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610106, China.[3]School of Pharmacy, Chengdu University, Chengdu 610106, China.
Chemical epigenetic cultivation of the sponge-derived fungus Pestalotiopsis sp. SWMU-WZ04-1 contributed to the identification of twelve polyketide derivatives, including six new pestalotiopols E-J (1-6) and six known analogues (7-12). Their gross structures were deduced from 1D/2D NMR and HRESIMS spectroscopic data, and their absolute configurations were further established by circular dichroism (CD) Cotton effects and the modified Mosher's method. In the bioassay, the cytotoxic and antibacterial activities of all compounds were evaluated. Chlorinated benzophenone derivatives 7 and 8 exhibited inhibitory effects on Staphylococcus aureus and Bacillus subtilis, with MIC values varying from 3.0 to 50 μg/mL. In addition, these two compounds were cytotoxic to four types of human cancer cells, with IC50 values of 16.2~83.6 μM. The result showed that compound 7 had the probability of being developed into a lead drug with antibacterial ability.
基金：
This work was funded by the Department of Science and Technology of Sichuan Province
(2022NSFSC0109), the Sichuan Science and Technology Program (2022YFS0624), the Open Project
of Sichuan Industrial Institute of Antibiotics, Chengdu University (ARRLKF20-04), the Applied
Basic Research Fund of the Second People’s Hospital of Deyang City-Southwest Medical University
(2022DYEXNYD004), and the Sichuan Traditional Chinese Medicine Administration (2023zd008).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区医学
小类|2 区药物化学2 区药学
最新[2023]版：
大类|2 区医学
小类|2 区药物化学2 区药学
第一作者：
第一作者机构：[1]School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Jiang Liyuan,Teng Baorui,Zhang Mengyu,et al.Pestalotiopols E-J, Six New Polyketide Derivatives from a Marine Derived Fungus Pestalotiopsis sp. SWMU-WZ04-1[J].Marine Drugs.2023,22(1):doi:10.3390/md22010015.
APA：
Jiang Liyuan,Teng Baorui,Zhang Mengyu,Chen Siwei,Zhang Dan...&Lei Hui.(2023).Pestalotiopols E-J, Six New Polyketide Derivatives from a Marine Derived Fungus Pestalotiopsis sp. SWMU-WZ04-1.Marine Drugs,22,(1)
MLA：
Jiang Liyuan,et al."Pestalotiopols E-J, Six New Polyketide Derivatives from a Marine Derived Fungus Pestalotiopsis sp. SWMU-WZ04-1".Marine Drugs 22..1(2023)
