机构：[1]Department of Orthopedics, Orthopedics Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[2]Trauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[3]School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610041, China.[4]Department of Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Currently, the use of piezoelectric materials to provide sustainable and noninvasive bioelectric stimulation to eradicate tumor cells and accelerate wound healing has raised wide attention. The development of a multifunctional piezoelectric elastomer with the ability to perform in situ tumor therapy as well as wound repair is of paramount importance. However, current piezoelectric materials have a large elastic modulus and limited stretchability, making it difficult to match with the dynamic curvature changes of the wound. Therefore, by copolymerizing lactic acid, butanediol, sebacic acid, and itaconic acid to develop a piezoelectric elastomer (PLBSIE), we construct a new ultrasound-activated PLBSIE-based tumor/wound unified therapeutic platform. Excitedly, it showed outstanding piezoelectric performance and high stretchability, and the separated carrier could react with water to generate highly cytotoxic reactive oxygen species (ROS), contributing to effectively killing tumor cells and eliminating bacteria through piezoelectric therapy. In addition, ultrasound-triggered piezoelectric effects could promote the migration and differentiation of wound-healing-related cells, thus accelerating wound healing. Herein, such a piezoelectric elastomer exerted a critical role in postoperative tumor-induced wound therapy and healing with the merits of possessing multifunctional abilities. Taken together, the developed ultrasound-activated PLBSIE will offer a comprehensive treatment for postoperative osteosarcoma therapy.
基金：
Natural Science Foundation
of Sichuan (2023NSFSC1835), the Tibet Autonomous Region
cofunded project (XZ202301ZY0046G), the Post-Doctor
Research Project of West China Hospital, Sichuan University
(2023HXBH106), and the China Postdoctoral Science
Foundation (2023M732467, 2023TQ0224).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
最新[2023]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]Department of Orthopedics, Orthopedics Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.[2]Trauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopedics, Orthopedics Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.[2]Trauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Deng Xiangtian,Zhao Renliang,Tang Yunfeng,et al.Highly Biocompatible Polyester-Based Piezoelectric Elastomer with Antitumor and Antibacterial Activity for Ultrasound-Enhanced Piezoelectric Therapy[J].ACS applied materials & interfaces.2023,doi:10.1021/acsami.3c11749.
APA：
Deng Xiangtian,Zhao Renliang,Tang Yunfeng,Yi Min,Ge Zilu...&Wang Guanglin.(2023).Highly Biocompatible Polyester-Based Piezoelectric Elastomer with Antitumor and Antibacterial Activity for Ultrasound-Enhanced Piezoelectric Therapy.ACS applied materials & interfaces,,
MLA：
Deng Xiangtian,et al."Highly Biocompatible Polyester-Based Piezoelectric Elastomer with Antitumor and Antibacterial Activity for Ultrasound-Enhanced Piezoelectric Therapy".ACS applied materials & interfaces .(2023)
材料科学