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Iridoids and bis-iridoids from Valeriana jatamansi and their cytotoxicity against human glioma stem cells

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机构: [a]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China [b]Laboratory of Animal Tumor Models, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, PR China [c]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, PR China [d]The First Department of Neurosurgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, 650101, Yunnan, PR China [e]Zoology Department, Faculty of Science, Minia University, Minia, 61519, Egypt
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关键词: Bis-iridoids Caprifoliaceae Cytotoxicity Human glioma stem cells Iridoids Valeriana jatamansi Valeridoids A-F

摘要:
An undescribed iridoid (valeridoid A) and five undescribed bis-iridoids (valeridoids B–F), along with four known ones, were isolated from the roots and rhizomes of Valeriana jatamansi. Their structures were elucidated based on 1D and 2D NMR, as well as HRESIMS spectroscopic data. In addition, 8,9-didehydro-7-hydroxydolichodial and valeridoid F were found to inhibit the growth of three human glioma stem cells (GSC-3#, GSC-12# and GSC-18#). © 2020 Elsevier Ltd

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出版当年[2020]版:
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
最新[2023]版:
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
第一作者:
第一作者机构: [a]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China
通讯作者:
通讯机构: [a]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China [b]Laboratory of Animal Tumor Models, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, PR China [c]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, PR China [*1]Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming South Road, Chenggong District, Kunming, 650500, Yunnan, PR China [*2]Laboratory of Animal Tumor Models, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, PR China.
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